Increased Expression of PD-L1 and PD-L2 in Dermal Fibroblasts From Alopecia Areata Mice

    August 2017 in “ Journal of Cellular Physiology ”
    Yunyuan Li, Ruhi T. Kilani, Mohammadreza Pakyari, Gigi Leung, Layla Nabai, Aziz Ghahary
    TLDR PD‐L1 and PD‐L2 may not effectively control immune activation in alopecia areata.
    The study investigated the expression of PD-L1 and PD-L2 in dermal fibroblasts from alopecia areata (AA) mice. It was found that AA-affected skin had a significantly higher number of PD-L1 and PD-L2 positive cells compared to non-AA skin. This increase was correlated with the presence of infiltrated T cells, particularly CD8+ T cells. The expression of these molecules was associated with biomarkers for dermal fibroblasts, such as type 1 pro-collagen, CD90, and vimentin. The study concluded that activated T cells in AA-affected skin up-regulated PD-L1 and PD-L2 expression in dermal fibroblasts, suggesting these molecules may not effectively control immune activation in AA lesions.
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