Increased Expression of PD-L1 and PD-L2 in Dermal Fibroblasts From Alopecia Areata Mice

    August 2017 in “ Journal of Cellular Physiology ”
    Yunyuan Li, Ruhi T. Kilani, Mohammadreza Pakyari, Gigi Leung, Layla Nabai, Aziz Ghahary
    TLDR PD‐L1 and PD‐L2 may not effectively control immune activation in alopecia areata.
    The study investigated the role of PD‐L1 and PD‐L2 in alopecia areata (AA), an autoimmune disorder causing hair loss. Researchers found that in AA-affected mice, there was a significant increase in PD‐L1 and PD‐L2 expression in dermal fibroblasts, which correlated with the presence of infiltrated T cells, particularly CD8+ T cells. These expressions were associated with biomarkers for dermal fibroblasts, such as type 1 pro-collagen, CD90, and vimentin. The study concluded that activated T cells in AA lesions up-regulated PD‐L1 and PD‐L2, suggesting these molecules might not effectively control immune activation in AA, contrary to their typical role in immune regulation.
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