Increased Expression of PD-L1 and PD-L2 in Dermal Fibroblasts From Alopecia Areata Mice

    August 2017 in “ Journal of Cellular Physiology ”
    Yunyuan Li, Ruhi T. Kilani, Mohammadreza Pakyari … Aziz Ghahary
    Studysummary In this study, researchers found that in mouse models of alopecia areata, the expression of immune-regulating molecules PD-L1 and PD-L2 in dermal fibroblasts is increased by activated T cells, potentially indicating a lack of negative immune control in affected skin.
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    Research cited in this study 5

    1. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    2. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    3. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013
    4. Alopecia Areata Update Journal of The American Academy of Dermatology · 2010
    5. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008

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