The Role of Exosomes in Follicle Regeneration of Androgenic Alopecia

    November 2023 in “ Journal of Drug Delivery Science and Technology ”
    Jiali Yao, Yu-Rou Shi, Xue- Er Hu, Dao‐Yi Yu, Bang-Yao Chen, Lijiang Wang, Xiaoling Xu, Mingjian Zhu
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    TLDR Exosomes may help stimulate hair growth and improve hair loss conditions like androgenic alopecia.
    The document discusses the increasing prevalence of hair loss, particularly androgenic alopecia (AGA), which affects both males and females. The pathogenesis of AGA is unclear, but it could be due to an abnormal sensitivity of scalp hair follicles to androgens or increased activity of type II 5α-reductase. Current treatments, including drug therapy and surgical treatments, have limitations and do not fundamentally cure hair loss. The document highlights the potential of nanocarriers in transdermal drug delivery for hair loss treatment, but notes that these can be easily recognized by the immune system and have low bioavailability. The document then introduces exosomes, vesicular substances secreted by cells, as a potential solution. Exosomes play a significant role in intercellular signal exchange and could invigorate recipient cells, potentially addressing the root causes of hair loss. The document concludes that exosomes, abundant in bioactive molecules, can stimulate the proliferation, differentiation, and survival of hair follicle cells, regulate the hair follicle cycle, and prompt hair follicles in the telogen phase to enter a new growth cycle early.
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