The Role of Exosomes in Follicle Regeneration of Androgenic Alopecia

    November 2023 in “ Journal of Drug Delivery Science and Technology ”
    Jiali Yao, Yu-Rou Shi, Xue- Er Hu, Dao‐Yi Yu, Bang-Yao Chen, Lijiang Wang, Xiaoling Xu, Mingjian Zhu
    Image of study
    TLDR Exosomes may help stimulate hair growth and improve hair loss conditions like androgenic alopecia.
    The document discusses the increasing prevalence of hair loss, particularly androgenic alopecia (AGA), which affects both males and females. The pathogenesis of AGA is unclear, but it could be due to an abnormal sensitivity of scalp hair follicles to androgens or increased activity of type II 5α-reductase. Current treatments, including drug therapy and surgical treatments, have limitations and do not fundamentally cure hair loss. The document highlights the potential of nanocarriers in transdermal drug delivery for hair loss treatment, but notes that these can be easily recognized by the immune system and have low bioavailability. The document then introduces exosomes, vesicular substances secreted by cells, as a potential solution. Exosomes play a significant role in intercellular signal exchange and could invigorate recipient cells, potentially addressing the root causes of hair loss. The document concludes that exosomes, abundant in bioactive molecules, can stimulate the proliferation, differentiation, and survival of hair follicle cells, regulate the hair follicle cycle, and prompt hair follicles in the telogen phase to enter a new growth cycle early.
    Discuss this study in the Community →

    Research cited in this study

    42 / 42 results

    Related Community Posts Join

    6 / 1000+ results
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community DHT/Testosterone levels in scalp Fin VS Dut.

      in Finasteride/Dutasteride  60 upvotes 5 months ago
      Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Experiences with Annurmets Hair?

      in Product  6 upvotes 3 years ago
      User asks about Annurmets Hair product, high in Procyanidin B2 for hair regrowth. Product is expensive and ordered from Italy.

    Similar Research

    5 / 1000+ results