Exploring the Potential of Natural Products in Treating Alopecia Areata

    January 2026 in “ Journal of Pharmaceutical Analysis ”
    Ben He, Yujia Weng, Peihua Luo … Xiaochun Yang
    Studysummary This review highlights the potential of natural compounds like terpenoids, flavonoids, and polyphenols in promoting hair regrowth for those with alopecia areata by activating growth pathways and modulating immune responses, but calls for further research to confirm their therapeutic utility.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 81

    1. Liposomes Enhance the Hair Follicle Delivery of Minoxidil Sulfate With Improved Treatment of Androgenic Alopecia International Journal of Pharmaceutics · 2025
    2. Deoxyshikonin From Arnebiae Radix Promotes Hair Growth By Targeting The Wnt/β-Catenin Signaling Pathway Phytomedicine · 2025
    3. In Vitro Hair Growth-Promoting Effects of Araliadiol via the p38/PPAR-γ Signaling Pathway in Human Hair Follicle Stem Cells and Dermal Papilla Cells Frontiers in Pharmacology · 2024
    4. Isoquercitrin Promotes Hair Growth Through Induction of Autophagy and Angiogenesis by Targeting AMPK and IGF-1R Phytomedicine · 2024
    5. Extraction, Purification, Structural Characterization, and Bioactivities of Ginkgo Biloba Leaf Polysaccharides: A Review International Journal of Biological Macromolecules · 2024
    6. Terminalia Bellirica (Gaertn.) Roxb. Extracts Reshape the Perifollicular Microenvironment and Regulate the MAPK Pathway for Androgenetic Alopecia Treatment Journal of Ethnopharmacology · 2024
    7. Mesenchymal Stem Cell Therapy in Alopecia Areata: Visual and Molecular Evidence from a Mouse Model International Journal of Molecular Sciences · 2024
    8. Cedrol in Ginger (Zingiber Officinale) as a Promising Hair Growth Drug: The Effects of Oral and External Administration on Hair Regeneration and Its Mechanism Bioorganic Chemistry · 2024
    9. Botanical Extract Combined with Minoxidil Improves Hidrotic Ectodermal Dysplasia Caused by p.G11R Mutations: A Case Report Journal of Dermatological Treatment · 2024
    10. Deciphering the Complex Immunopathogenesis of Alopecia Areata International Journal of Molecular Sciences · 2024
    11. Amygdalin Ameliorates Alopecia Areata on C3H/HeJ Mice by Inhibiting Inflammation Through JAK2/STAT3 Pathway Journal of Ethnopharmacology · 2024
    12. Interleukin-15 Is a Hair Follicle Immune Privilege Guardian Journal of Autoimmunity · 2024
    13. Salvianolic Acid B Reduces Oxidative Stress to Promote Hair Growth in Mice, Human Hair Follicles, and Dermal Papilla Cells Clinical, cosmetic and investigational dermatology · 2024
    14. Ginsenosides in Panax Ginseng Extract Promote Anagen Transition by Suppressing BMP4 Expression and Promote Human Hair Growth by Stimulating Follicle-Cell Proliferation Biological & pharmaceutical bulletin · 2024
    15. European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    16. Hair Growth-Promoting Effects of Rosehip (Rosa canina L.) Seed Oil in C57BL/6 Mice Journal of Food Science and Nutrition · 2023
    17. Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions Frontiers in immunology · 2023
    18. Methodologies to Evaluate the Hair Follicle-Targeted Drug Delivery Provided by Nanoparticles Pharmaceutics (Basel) · 2023
    19. Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism of Action Current Issues in Molecular Biology · 2023
    20. Ginsenoside CK Inhibits Androgenetic Alopecia by Regulating Wnt/Beta-Catenin and P53 Signaling Pathways in AGA Mice Food frontiers · 2023
    21. Panax Notoginseng Saponins Promote Hair Follicle Growth in Mice via Wnt/Beta-Catenin Signaling Pathway Chemical biology & drug design · 2023
    22. Curcumin-Zinc Framework Encapsulated Microneedle Patch for Promoting Hair Growth Theranostics · 2023
    23. The Philippines Stingless Bee Propolis Promotes Hair Growth Through Activation of Wnt/Beta-Catenin Signaling Pathway Jikken Dobutsu · 2022
    24. How Our Microbiome Influences the Pathogenesis of Alopecia Areata Genes · 2022
    25. Cucurbitacin Promotes Hair Growth in Mice by Inhibiting the Expression of Fibroblast Growth Factor 18 Annals of Translational Medicine · 2022
    26. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    27. The Emergent Power of Human Cellular vs Mouse Models in Translational Hair Research Stem Cells Translational Medicine · 2022
    28. Lagerstroemia Indica Extract Regulates Human Hair Dermal Papilla Cell Growth and Degeneration via Modulation of β-Catenin, Stat6, and TGF-β Signaling Pathway Journal of Cosmetic Dermatology · 2022
    29. Exploring the Effects of Chinese Herbal Ingredients on the Signaling Pathway of Alopecia and Screening Effective Compounds Journal of Ethnopharmacology · 2022
    30. Efficacy of a Mixed Preparation Containing Piperine, Capsaicin, and Curcumin in the Treatment of Alopecia Areata Journal of cosmetic dermatology · 2022
    31. Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata International journal of molecular sciences · 2022
    32. Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles, and Dermal Papilla Cells Clinical, Cosmetic and Investigational Dermatology · 2021
    33. Hair-Growth Promoting Effect and Anti-Inflammatory Mechanism of Ginkgo Biloba Polysaccharides Carbohydrate Polymers · 2021
    34. Hair Growth-Promoting Mechanisms of Red Ginseng Extract Through Stimulating Dermal Papilla Cell Proliferation and Enhancing Skin Health Journal of Food Science and Nutrition · 2021
    35. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    36. Hair Growth Stimulation Effect of Centipeda Minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways Biomolecules · 2021
    37. Alopecia Areata: An Autoimmune Disease of Multiple Players ImmunoTargets and therapy · 2021
    38. Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2021
    39. Hair Growth Promotion Effect of Nelumbinis Semen Extract with High Antioxidant Activity Evidence-based Complementary and Alternative Medicine · 2021
    40. Red Ginseng Oil Promotes Hair Growth and Protects Skin Against UVC Radiation Journal of Ginseng Research · 2021
    41. Ent-Kaurane-Type Diterpenoids from Isodonis Herba Activate Human Hair Follicle Dermal Papilla Cells Proliferation via the Akt/GSK-3β/β-Catenin Transduction Pathway Journal of Natural Medicines · 2021
    42. Cepharanthine Induces Proliferation of Human Dermal Papilla Cells and Stimulates Vascular Endothelial Growth Factor Expression Through Increased Intracellular Calcium Mobilization and Hypoxia-Inducible Factor Activation Clinical and Experimental Dermatology · 2020
    43. The Antiinflammatory Effects of Xuefu Zhuyu Decoction on C3H/HeJ Mice With Alopecia Areata Phytomedicine · 2020
    44. Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway Molecules · 2020
    45. The Versatility of Azelaic Acid in Dermatology Journal of Dermatological Treatment · 2020
    46. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    47. Getting Under the Skin of Hair Aging: The Impact of the Hair Follicle Environment Experimental Dermatology · 2020
    48. Ginsenoside Rb1 Retards Aging Process by Regulating Cell Cycle, Apoptotic Pathway, and Metabolism of Aging Mice Journal of ethnopharmacology · 2020
    49. Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/β-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2019
    50. Ginkgolide B and Bilobalide Promote Growth and Increase β-Catenin Expression in Hair Follicle Dermal Papilla Cells of American Minks BioFactors · 2019
    51. Costunolide: A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential International Journal of Molecular Sciences · 2019
    52. Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/β-Catenin Signaling Activation in 3-Dimensional Spheroid Cultured Human Dermal Papilla Cells Journal of Microbiology and Biotechnology · 2019
    53. Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients International journal of environmental research and public health/International journal of environmental research and public health · 2018
    54. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    55. Costunolide Promotes the Proliferation of Human Hair Follicle Dermal Papilla Cells and Induces Hair Growth in C57BL/6 Mice Journal of Cosmetic Dermatology · 2018
    56. Nature-Derived Lignan Compound VB-1 Exerts Hair Growth-Promoting Effects by Augmenting Wnt/β-Catenin Signaling in Human Dermal Papilla Cells PeerJ · 2018
    57. Immune Privilege Collapse And Alopecia Development: Is Stress A Factor Skin Appendage Disorders · 2017
    58. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    59. Beta-Catenin Is Involved in Oleanolic Acid-Dependent Promotion of Proliferation in Human Hair Matrix Cells in an In Vitro Organ Culture Model Fitoterapia · 2017
    60. Effect of Miscanthus Sinensis Var. Purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice Chinese Journal of Integrative Medicine · 2017
    61. Hair Growth-Promoting Effect of Geranium Sibiricum Extract in Human Dermal Papilla Cells and C57BL/6 Mice BMC Complementary and Alternative Medicine · 2017
    62. Topical Treatment of Hair Loss with Formononetin by Modulating Apoptosis Planta Medica · 2016
    63. Artepillin C and Other Herbal PAK1-Blockers: Effects on Hair Cell Proliferation and Related PAK1-Dependent Biological Function in Cell Culture Phytotherapy Research · 2015
    64. The Ginsenosides of Panax Ginseng Promote Hair Growth via Similar Mechanism of Minoxidil Journal of Dermatological Science · 2015
    65. Stimulatory Effect of Brazilian Propolis on Hair Growth Through Proliferation of Keratinocytes in Mice Journal of Agricultural and Food Chemistry · 2014
    66. Diagnosis and Management of Alopecia in Children Pediatric Clinics of North America · 2014
    67. A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice Bioscience, Biotechnology, and Biochemistry · 2013
    68. 6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice PLOS ONE · 2013
    69. Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata Clinical and Developmental Immunology · 2013
    70. Ginsenosides Rb1 and Rd Regulate Proliferation of Mature Keratinocytes Through Induction of p63 Expression in Hair Follicles PTR. Phytotherapy research/Phytotherapy research · 2012
    71. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    72. Fructus Panax Ginseng Extract Promotes Hair Regeneration in C57BL/6 Mice Journal of Ethnopharmacology · 2011
    73. Curcuma Aeruginosa, A Novel Botanically Derived 5α-Reductase Inhibitor In The Treatment Of Male-Pattern Baldness: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Journal of Dermatological Treatment · 2011
    74. Dietary Isoflavone Increases Insulin-Like Growth Factor-I Production, Thereby Promoting Hair Growth in Mice The Journal of Nutritional Biochemistry · 2011
    75. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    76. Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG) Phytomedicine · 2006
    77. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    78. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    79. Comparison of Azelaic Acid and Anthralin for the Therapy of Patchy Alopecia Areata American Journal of Clinical Dermatology · 2005
    80. Dietary Soy Oil Content and Soy-Derived Phytoestrogen Genistein Increase Resistance to Alopecia Areata Onset in C3H/HeJ Mice Experimental Dermatology · 2003
    81. Effect of Leaves of Ginkgo Biloba on Hair Regrowth in C3H Strain Mice Yakugaku zasshi · 1993