Dietary Soy Oil Content and Soy-Derived Phytoestrogen Genistein Increase Resistance to Alopecia Areata Onset in C3H/HeJ Mice

    February 2003 in “ Experimental Dermatology ”
    Kevin J. McElwee, Shuhei Niiyama, Pia Freyschmidt‐Paul, Elke Wenzel, Sabine Kissling, John P. Sundberg, R. Hoffmann
    TLDR Soy oil and genistein reduce hair loss risk in mice.
    The study investigated the impact of dietary soy oil and the soy-derived phytoestrogen genistein on the onset of alopecia areata (AA) in C3H/HeJ mice. Mice were grafted with skin from AA-affected mice and fed diets with varying soy oil content (1%, 5%, and 20%). Results showed that 86% of mice on a 1% soy oil diet developed AA, compared to 39% on a 5% diet and 18% on a 20% diet. Additionally, genistein injections in mice on a 1% soy oil diet resulted in 40% developing AA, compared to 90% in the control group. The study suggested that soy oil and its derivatives might influence AA susceptibility through estrogen-dependent mechanisms or by modulating inflammatory activity.
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