Costunolide Promotes the Proliferation of Human Hair Follicle Dermal Papilla Cells and Induces Hair Growth in C57BL/6 Mice

    May 2018 in “ Journal of Cosmetic Dermatology ”
    Young Eun Kim, Hyung Chul Choi, Gnu Nam, Bu Young Choi
    Studysummary This study found that costunolide promotes hair growth in both lab-cultured human hair follicle cells and in live mice by modulating growth factor pathways.
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    Research cited in this study 12

    1. Costunolide Promotes the Proliferation of Human Hair Follicle Dermal Papilla Cells and Induces Hair Growth in C57BL/6 Mice Journal of Cosmetic Dermatology · 2018
    2. Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia Expert Opinion on Therapeutic Targets · 2014
    3. Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering Expert Opinion on Biological Therapy · 2013
    4. Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay Journal of Investigative Dermatology · 2011
    5. Contemporary Hair Transplantation Dermatologic Surgery · 2009
    6. Reorganization of Hair Follicles in Human Skin Organ Culture Induced by Cultured Human Follicle-Derived Cells Experimental Dermatology · 2005
    7. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    8. Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology Journal of Investigative Dermatology · 2003
    9. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    10. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    11. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    12. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999

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