Cedrol in Ginger (Zingiber Officinale) as a Promising Hair Growth Drug: The Effects of Oral and External Administration on Hair Regeneration and Its Mechanism

    August 2024 in “ Bioorganic Chemistry
    Jia Li, Guiming Zhang, Xinyang Zhou, Jian Guan, Wenjie Zhao, Yifei Zheng, Jungjoon Lee, Peng Wang, Yuqing Zhao
    The study explores Cedrol (CE) from ginger for hair regeneration in cyclophosphamide-induced alopecia areata in mice, finding oral administration (OA) more effective than external application (EA) in promoting hair growth, reducing follicle damage, and enhancing cell proliferation. CE works by regulating the JAK3/STAT3 signaling pathway, activating the Wnt3α/β-catenin germinal center, and reducing oxidative stress, indicating its potential for developing oral hair growth treatments.
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