Cedrol Mitigates Hepatic Lipid Accumulation and Adipocyte Hypertrophy Induced by Corticosteroids Through the Inhibition of Glucocorticoid Receptor Activity

December 2025 in “ Scientific Reports ”

M.J. Shu, Pan Wang

cedrol glucocorticoid receptor dexamethasone glucocorticoids ginger cedar oil

Studysummary In this study, cedrol was found to reduce lipid accumulation in the liver and adipose tissues of dexamethasone-treated mice by antagonizing glucocorticoid receptors, suggesting its potential utility in treating dexamethasone-induced lipid metabolism disorders. Our plain-language summary of this paper — not a Tressless recommendation.

Cedrol, a compound derived from ginger and cedar oil, has been shown to mitigate lipid accumulation in the liver and adipose tissues of adult male mice induced by the glucocorticoid dexamethasone. The study reveals that cedrol inhibits the expression of genes related to lipid metabolism and demonstrates antagonistic activity against glucocorticoid receptors (GRs). These findings suggest that cedrol's GR antagonist activity may underlie its effects on lipid metabolism, indicating its potential use in treating lipid metabolism disorders caused by high levels of glucocorticoids.

View this study on nature.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Involvement of the Central Hypothalamic-Pituitary-Adrenal Axis in Hair Growth and Melanogenesis Among Different Mouse Strains

6 citations , October 2018 in “PLoS ONE”

This study found that chronic stress may inhibit hair follicle growth and melanogenesis in mice through modulation of the central HPA axis, with C57BL/6 mice appearing most sensitive to these effects.

research Hair Growth Promoting Activity of Cedrol Isolated from the Leaves of Platycladus Orientalis

39 citations , July 2016 in “Biomedicine & Pharmacotherapy”

In this animal study, researchers found that cedrol, a constituent from Platycladus orientalis, significantly promoted hair growth in a dose-dependent manner in female C57BL/6 mice, surpassing results from blank control and 2% minoxidil groups over 21 days.