TLDR New research on prostamide F2α has led to treatments for glaucoma and eyelash growth and may have more medical uses.
The document from July 26, 2013, discusses the advancements in prostamide F2α research, particularly focusing on the pharmacology of bimatoprost, an antiglaucoma drug that shares similar properties with prostamide F2α. Early studies compared the potency of bimatoprost with prostaglandin F2α and synthetic FP receptor agonists, leading to the development of selective prostamide receptor antagonists, which helped distinguish prostamide effects from FP receptor-mediated effects. Bimatoprost has been therapeutically used to treat glaucoma and eyelash hypotrichosis and has been shown to stimulate hair growth in human scalp hair follicles and mouse pelage hair. Additionally, bimatoprost may reduce fat deposition by targeting preadipocytes. The discovery of prostamide/PGF synthase has been crucial in understanding the distribution of prostamide F2α, with high expression in the central nervous system indicating its role as a nociceptive mediator in the spinal cord. Bimatoprost has provided therapeutics in multiple areas, and the use of prostamide agonists and antagonists may lead to further medical applications.
53 citations,
October 2012 in “The FASEB Journal” Bimatoprost, a glaucoma medication, may also help treat hair loss.
29 citations,
May 2010 in “Ophthalmology” Bimatoprost gel makes eyelashes grow longer, but may cause side effects and should be monitored by an eye doctor.
69 citations,
April 2010 in “Dermatologic Surgery” Bimatoprost is a safe and effective treatment for making eyelashes longer, thicker, and darker.
23 citations,
April 2010 in “Clinical, cosmetic and investigational dermatology” Bimatoprost ophthalmic solution 0.03% safely and effectively increases eyelash growth when applied to the upper eyelid.
35 citations,
March 2010 in “British journal of dermatology/British journal of dermatology, Supplement” The study showed that mouse eyelashes can be used to study eyelash growth and that bimatoprost makes them longer and more numerous.
37 citations,
January 2010 in “International Journal of Trichology” Bimatoprost helped eyelash growth in nearly half of the patients with a type of eyelash hair loss.
38 citations,
March 2017 in “Expert Opinion on Investigational Drugs” Bimatoprost is promising for treating some types of hair loss but needs more testing for androgenetic alopecia.
53 citations,
October 2012 in “The FASEB Journal” Bimatoprost, a glaucoma medication, may also help treat hair loss.
69 citations,
April 2010 in “Dermatologic Surgery” Bimatoprost is a safe and effective treatment for making eyelashes longer, thicker, and darker.
69 citations,
April 2010 in “Clinical ophthalmology” Bimatoprost is effective for growing longer, thicker, and darker eyelashes.
31 citations,
January 2015 in “Journal of The American Academy of Dermatology” Prostaglandin F2α analogs show promise for treating certain types of hair loss but need more research for other skin conditions.
