Prostaglandin F2α Stimulates Growth of Human Intermediate Hair Follicles in Ex Vivo Organ Culture with Potential Clinical Relevance

    June 2025 in “ Frontiers in Physiology ”
    Benjamin H. Miranda, Karzan Ghafur Khidhir, Desmond J. Tobin
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    TLDR Prostaglandin F2α may help treat hair loss by promoting hair growth.
    The study investigates the effects of Prostaglandin F2α (PGF2α) on human intermediate hair follicles using an ex vivo organ culture model with samples from 6 female donors. It found that PGF2α stimulates hair growth by extending the anagen phase, with terminal follicles showing more growth than intermediate ones. The growth stimulation was inhibited by a PGF2α receptor antagonist, confirming the role of FP receptors. The findings suggest potential clinical relevance for PGF2α in treating hair loss conditions like alopecia, although the long-term effects remain uncertain. The study emphasizes the importance of human hair follicle models over rodent models due to differences in hair loss disorders.
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