Botanical Extract Combined with Minoxidil Improves Hidrotic Ectodermal Dysplasia Caused by p.G11R Mutations: A Case Report

This case report details the treatment of a 6-year-old male with hidrotic ectodermal dysplasia 2 (HED2) due to a GJB6 (p.G11R) mutation, using botanical extracts combined with 5% minoxidil. The treatment led to significant hair growth after 1.5 months, suggesting it as a promising and safe strategy for congenital alopecia in children. The study emphasizes the psychological benefits of addressing hair issues in HED2 patients and notes the potential of botanical extracts in treating hair loss. Despite challenges like obtaining consent for trichograms, the report underscores the need for further research to understand the mechanism of the licorice extract used, offering valuable insights for future studies.