Botanical Extract Combined with Minoxidil Improves Hidrotic Ectodermal Dysplasia Caused by p.G11R Mutations: A Case Report

July 2024 in “ Journal of Dermatological Treatment ”

Shiyi Zhong, Chuhan Huang, Mingyue Zhuang, Qingwu Liu, Zhao-hui Tian, Dingquan Yang

botanical extract minoxidil hidrotic ectodermal dysplasia GJB6 mutations p.G11R mutations diffuse thinning fine and brittle hair Rogaine

TLDR Botanical extracts and Minoxidil improved hair condition in a boy with a genetic disorder.

This case report details the treatment of a 6-year-old male with hidrotic ectodermal dysplasia 2 (HED2) due to a GJB6 (p.G11R) mutation, using botanical extracts combined with 5% minoxidil. The treatment led to significant hair growth after 1.5 months, suggesting it as a promising and safe strategy for congenital alopecia in children. The study emphasizes the psychological benefits of addressing hair issues in HED2 patients and notes the potential of botanical extracts in treating hair loss. Despite challenges like obtaining consent for trichograms, the report underscores the need for further research to understand the mechanism of the licorice extract used, offering valuable insights for future studies.

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Research cited in this study

research Botanical Extracts in Combination Improve Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Mutations

research Isolated Autosomal Recessive Woolly Hair/Hypotrichosis: Genetics, Pathogenesis, and Therapies

research Hypohidrotic Ectodermal Dysplasia with c.28delG Mutation in Ectodysplasin A Gene and Severe Atopic Dermatitis Treated Successfully with Tofacitinib

research Minoxidil And Its Use In Hair Disorders: A Review

research Assessment of a Bidirectional Association Between Major Depressive Disorder and Alopecia Areata

research Efficacy and Safety of Minoxidil 5% Foam in Combination With a Botanical Hair Solution in Men With Androgenic Alopecia

research Efficacy and Safety of Minoxidil 2% Solution in Combination With a Botanical Hair Solution in Women With Female Pattern Hair Loss/Androgenic Alopecia

research A Bibliometric Study of Scientific Literature in Scopus on Botanicals for Treatment of Androgenetic Alopecia

research Total Glucosides of Paeony Capsule Plus Compound Glycyrrhizin Tablets for the Treatment of Severe Alopecia Areata in Children: A Randomized Controlled Trial

research Monilethrix Treated with Minoxidil

research Minoxidil: Mechanisms of Action on Hair Growth

research Alopecia Universalis Associated With a Mutation in the Human Hairless Gene

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