Isoquercitrin Promotes Hair Growth Through Induction of Autophagy and Angiogenesis by Targeting AMPK and IGF-1R

The study investigates the effects of isoquercitrin (IQ) on hair regrowth, demonstrating that IQ promotes hair growth by facilitating the transition of hair follicles into the anagen phase. This is achieved through the induction of autophagy and angiogenesis by targeting the AMPK/mTOR/ULK1 and IGF-1R/PI3K/AKT signaling pathways. The research highlights the potential of IQ as a therapeutic approach for hair regeneration, suggesting that targeting these pathways could be promising for treating hair loss. The study used a dorsal skin model in rats, comparing the effects of IQ with minoxidil, a common hair loss treatment, and found that both treatments effectively promoted hair regrowth.