Bazi Bushen Capsule Alleviates Skin Photoaging by Targeting the KEAP1–NRF2 Pathway

October 2025 in “ Phytomedicine ”

Yu-Ning Jiang, Mengnan Li, Hongrong Li, Yawen Li, Zhifang Guo, Xingyu Xing, Kunxu Niu, Runtao Zhang, Xiaohong Lu, Zhiqin Zhao, Liangxing Zhou, Ting‐Guo Kang, Yunlong Hou, Yiling Wu

Bazi Bushen capsule KEAP1–NRF2 pathway β-Nicotinamide Mononucleotide NMN UV-induced skin damage hair follicle growth NRF2 expression oxidative stress verbascoside epimedin A oxidative senescence Bazi Bushen

TLDR Bazi Bushen capsules reduce skin aging and damage from UV rays.

The study explores the effects of Bazi Bushen (BZBS) capsules on skin photoaging, emphasizing the KEAP1–NRF2 pathway. Experiments on mice showed that BZBS and β-Nicotinamide Mononucleotide (NMN) reduced UV-induced skin damage, promoted hair follicle growth, and decreased inflammation. BZBS enhanced NRF2 expression, reducing oxidative stress and aging signs. Key compounds, verbascoside and epimedin A, bind to KEAP1, preventing NRF2 degradation and alleviating oxidative senescence. The study highlights BZBS's potential as an anti-aging treatment by mitigating oxidative stress and inflammation, suggesting its promise in treating skin and hair conditions related to aging.

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Bazi Bushen Capsule Alleviates Skin Photoaging by Targeting the KEAP1–NRF2 Pathway

Research cited in this study

research Isoquercitrin Promotes Hair Growth Through Induction of Autophagy and Angiogenesis by Targeting AMPK and IGF-1R

research Age-Related Variations in Active Secondary Hair Follicles, Oxidative Stress, and Antioxidant Parameters in Cashmere Goats

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research Modeling of Solar UV-Induced Photodamage on the Hair Follicles in Human Skin Organoids

research Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in Various Pelage Hair Follicle Types

research Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond?

research Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices

research Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

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research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

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