Bazi Bushen Capsule Alleviates Skin Photoaging by Targeting the KEAP1–NRF2 Pathway

October 2025 in “ Phytomedicine ”

Yu-Ning Jiang, Mengnan Li, Hongrong Li, Yawen Li, Zhifang Guo, Xingyu Xing, Kunxu Niu, Runtao Zhang, Xiaohong Lu, Zhiqin Zhao, Liangxing Zhou, Ting‐Guo Kang, Yunlong Hou, Yiling Wu

Bazi Bushen capsule KEAP1–NRF2 pathway β-Nicotinamide Mononucleotide NMN UV-induced skin damage hair follicle growth NRF2 expression oxidative stress verbascoside epimedin A oxidative senescence Bazi Bushen

Studysummary This study demonstrates that Bazi Bushen capsules may have therapeutic potential against skin photoaging in mice by enhancing NRF2 expression and targeting the KEAP1-NRF2 pathway.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study explores the effects of Bazi Bushen (BZBS) capsules on skin photoaging, emphasizing the KEAP1–NRF2 pathway. Experiments on mice showed that BZBS and β-Nicotinamide Mononucleotide (NMN) reduced UV-induced skin damage, promoted hair follicle growth, and decreased inflammation. BZBS enhanced NRF2 expression, reducing oxidative stress and aging signs. Key compounds, verbascoside and epimedin A, bind to KEAP1, preventing NRF2 degradation and alleviating oxidative senescence. The study highlights BZBS's potential as an anti-aging treatment by mitigating oxidative stress and inflammation, suggesting its promise in treating skin and hair conditions related to aging.

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Research cited in this study

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