Angiopoietin-1 Induces Survival and Proliferation of Hair Follicle Dermal Papilla Cells Through Integrin α5β1 Signaling

    September 2025 in “ Frontiers in Medicine ”
    Jang-Hyuk Yun
    Studysummary This study found that angiopoietin-1 significantly reduces apoptosis and promotes proliferation in human follicle dermal papilla cells under DHT-induced stress, suggesting its potential as a therapeutic candidate for androgenetic alopecia.
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    Research cited in this study 30

    1. Androgenetic Alopecia 2025
    2. Isoquercitrin Promotes Hair Growth Through Induction of Autophagy and Angiogenesis by Targeting AMPK and IGF-1R Phytomedicine · 2024
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    9. VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK Experimental Cell Research · 2012
    10. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    11. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
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    13. Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects International Journal of Trichology · 2009
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    24. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    25. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
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    27. Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles Journal of Investigative Dermatology · 1995
    28. Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects Journal of The American Academy of Dermatology · 1993
    29. The Psychological Effects of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 1992
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