5 citations
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November 2022 in “Journal of Ginseng Research/Journal of ginseng research” This study investigated the role of autophagy in human dermal papilla cells and found that inhibiting autophagy accelerates the catagen phase by reducing Wnt/β-catenin signaling. Furthermore, adding ginsenoside Re appears to restore autophagy, suggesting potential benefits for mitigating hair loss linked to autophagy inhibition.
1 citations
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August 2022 in “Journal of Dermatological Treatment” In this study, the authors reported that oral dutasteride at 0.5 mg/day showed a probable greater efficacy in treating male androgenetic alopecia compared to finasteride and minoxidil, but it may cause sexual dysfunction and neuropsychiatric side effects.
25 citations
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June 2022 in “Developmental cell” In this study, Hedgehog signaling in dermal papilla fibroblasts was found to accelerate hair growth and induce follicle multiplication in mice via the SCUBE3/TGF-β pathway, with some effects observed in human scalp hair follicles.
21 citations
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March 2021 This study reviewed the literature on low-dose oral minoxidil as a primary treatment for various hair loss disorders, concluding that it is a successful and well-tolerated alternative to topical minoxidil for patients with poor adherence to other therapies.
23 citations
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January 2021 in “Biomedicine & Pharmacotherapy” This study found that dihydrotestosterone induced hair loss and changes in hair morphology in male C57BL/6 mice, effects that could be partially reversed by the AR antagonist bicalutamide.
59 citations
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July 2020 in “Journal of The American Academy of Dermatology” This study concluded that oral minoxidil is an effective and well-tolerated alternative to topical minoxidil for healthy patients struggling with application-related compliance issues.
28 citations
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May 2019 in “Life Sciences” This study found that ginsenoside Rb1 promoted the growth of mink hair follicles and dermal papilla cells, potentially through activating the PI3K/AKT/GSK-3β signaling pathway.
2 citations
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April 2019 in “Journal of Investigative Dermatology” This study found that overexpression of Gasdermin A3 in mice disrupts the hair follicle stem cell niche and causes hair loss through cell necrosis and abnormal hair cycle progression, without involving immune-mediated mechanisms.
12 citations
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September 2018 in “Dermatologic Therapy” This study found that 14 days of low-dose aspirin reduced the predicted response to topical minoxidil in androgenetic alopecia patients from 50% to 27%, suggesting aspirin may inhibit minoxidil efficacy.
18 citations
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September 2018 in “Current Pharmaceutical Design” This review discusses the recent progress of medicinal plants for treating hair loss and their suggested mechanisms, but reports no new clinical results.
23 citations
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January 2018 in “International Journal of Molecular Medicine” This study reported that baicalin activates the Wnt/β-catenin signaling pathway in mouse hair follicles, suggesting its potential as a topical treatment for hair loss.
8 citations
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January 2015 in “Experimental Dermatology” This commentary honors Shoji Okuda's pioneering but overlooked work on hair transplantation techniques from 1939, detailing comprehensive experiments that were rediscovered and translated into English decades later.
18 citations
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November 2014 in “Journal of Agricultural and Food Chemistry” This study found that ethanol-extracted propolis stimulated hair growth in mice by promoting the proliferation of hair keratinocytes.
42 citations
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March 2014 in “European Journal of Pharmacology” This study found that minor ginseng saponin F2 may promote hair growth more effectively than finasteride by enhancing anagen induction and modulating the Wnt signaling pathway in cell and mouse models.
11 citations
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April 2013 in “Journal of Agricultural and Food Chemistry” This study found that Monascus cursory extraction reduced baldness, prostate hyperplasia, and tumor incidence in animal models of androgen-related diseases, suggesting it may be a promising new therapeutic candidate.
15 citations
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September 2012 in “PTR. Phytotherapy research/Phytotherapy research” In this study, topical application of ginsenosides Rb₁ and Rd in mice increased cell proliferation in hair follicles, suggesting they may help prevent hair loss by promoting growth through p63 induction.
212 citations
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September 2008 in “Journal of The American Academy of Dermatology” This review discusses the various treatment options for male and female pattern hair loss and provides no new clinical results; the authors outline the most effective strategies based on existing evidence.
195 citations
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June 2005 in “American Journal of Human Genetics” Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.