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Glossaryp53 Signaling Pathway

regulates cell cycle and prevents cancer by responding to DNA damage

The p53 Signaling Pathway, also known as the TP53 Pathway, is a crucial cellular mechanism that helps regulate the cell cycle and prevent cancer. The p53 protein, often called the "guardian of the genome," activates in response to DNA damage or stress, leading to cell cycle arrest, DNA repair, or apoptosis (programmed cell death) to maintain genetic stability.

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research Ginsenoside CK Inhibits Androgenetic Alopecia by Regulating Wnt/Beta-Catenin and P53 Signaling Pathways in AGA Mice

June 2023 in “Food frontiers”

Ginsenoside CK, found in Panax ginseng, can prevent hair loss by controlling certain growth pathways and promoting hair follicle development.

research CXXC5: A Novel Regulator and Coordinator of TGF-β, BMP, and Wnt Signaling

28 citations, November 2018 in “Journal of Cellular and Molecular Medicine”

CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.

research Epimorphic Regeneration in Mice Is p53-Independent

20 citations, September 2010 in “Cell Cycle”

Mice can regenerate ear tissue without the p53 protein.

research Identification of Blood MicroRNA Alterations in Patients With Severe Active Alopecia Areata

15 citations, April 2019 in “Journal of Cellular Biochemistry”

Certain blood miRNAs are linked to severe alopecia areata and could lead to new treatments.

Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

2 citations, August 2020 in “Scientific reports”

Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.

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community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 1 year ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.