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    Glossary p14ARF

    regulates cell cycle and prevents tumor formation

    p14ARF is a protein that plays a crucial role in regulating the cell cycle and preventing tumor formation. It acts as a tumor suppressor by interacting with another protein called MDM2, which in turn stabilizes the p53 protein, a key player in controlling cell division and apoptosis (programmed cell death). This mechanism helps prevent cells from growing uncontrollably, which is important in cancer prevention.

    Research 2 of 51

    1. 138: Induction of cellular senescence and hair follicle stem cell dysfunction upon p14ARF and p16Ink4a expression in the skin European Journal of Cancer · 2014
    2. BMI1 is required for melanocyte stem cell maintenance and hair pigmentation Pigment Cell & Melanoma Research · 2023 · 4 citations
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