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    Glossary p14ARF

    regulates cell cycle and prevents tumor formation

    p14ARF is a protein that plays a crucial role in regulating the cell cycle and preventing tumor formation. It acts as a tumor suppressor by interacting with another protein called MDM2, which in turn stabilizes the p53 protein, a key player in controlling cell division and apoptosis (programmed cell death). This mechanism helps prevent cells from growing uncontrollably, which is important in cancer prevention.

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    1. 138: Induction of cellular senescence and hair follicle stem cell dysfunction upon p14ARF and p16Ink4a expression in the skin European Journal of Cancer · 2014
    2. BMI1 is required for melanocyte stem cell maintenance and hair pigmentation Pigment Cell & Melanoma Research · 2023 · 4 citations
    3. Removing all obstacles: A critical role for p53 in promoting tissue renewal Cell Cycle · 2010 · 30 citations
    4. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease Genes & Development · 2008 · 667 citations
    5. Molecular Regulation of Melanocyte Senescence Pigment Cell Research · 2002 · 85 citations
    6. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    7. Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update Mechanisms of Ageing and Development · 2018 · 19 citations
    8. ESGCT and FSGT Collaborative Congress Helsinki, Finland September 17–20, 2015 Abstracts Human Gene Therapy · 2015 · 2 citations
    9. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    10. Actinic Keratosis: Risk Factors, Clinical, Diagnosis and Therapeutics Aspects. Part I Dermatovenerologiâ, kosmetologiâ · 2024
    11. Australasian Society for Dermatology Research Meeting, May 2006 Journal of Investigative Dermatology · 2007
    12. MicroRNA control of signal transduction Nature Reviews Molecular Cell Biology · 2010 · 1066 citations
    13. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    14. A matter of life and death: self‐renewal in stem cells EMBO Reports · 2012 · 150 citations
    15. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    16. Stem cells and aberrant signaling of molecular systems in skin aging Ageing Research Reviews · 2014 · 25 citations
    17. Tailored chromatin modulation to promote tissue regeneration Seminars in Cell & Developmental Biology · 2019 · 10 citations
    18. H2AK119ub dynamics control hair follicle stem cell quiescence Nature Communications · 2025 · 2 citations
    19. Role of the Wnt signaling pathway in keratoacanthoma Cancer reports · 2019 · 2 citations
    20. Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence GeroScience · 2024
    21. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL Nature communications · 2016 · 665 citations
    22. Is knowledge about the genetic and epigenetic alterations in melanoma a basis for targeted therapy? Experimental Dermatology · 2006
    23. Topical Application of Thymidine Dinucleotide to Newborn Mice Reduces and Delays Development of UV-Induced Melanomas 2012 · 5 citations
    24. Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy Cell death and differentiation · 2015 · 56 citations
    25. Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells Medical Sciences · 2017 · 37 citations
    26. Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies Journal of Cellular and Molecular Medicine · 2009 · 36 citations
    27. S100A4/Nonmuscle Myosin IIA/p53 Axis Contributes to Aggressive Features in Ovarian High-Grade Serous Carcinoma American Journal Of Pathology · 2020 · 32 citations
    28. Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress during Hair Cycling PloS one · 2015 · 22 citations
    29. Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo International Journal of Molecular Sciences · 2023 · 21 citations
    30. Merkel cell carcinoma: updates in tumor biology, emerging therapies, and preclinical models Frontiers in Oncology · 2024 · 17 citations