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    Glossary p53 Signaling Pathway

    regulates cell cycle and prevents cancer by responding to DNA damage

    The p53 Signaling Pathway, also known as the TP53 Pathway, is a crucial cellular mechanism that helps regulate the cell cycle and prevent cancer. The p53 protein, often called the "guardian of the genome," activates in response to DNA damage or stress, leading to cell cycle arrest, DNA repair, or apoptosis (programmed cell death) to maintain genetic stability.

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    1. VDAC2 Mediates the Apoptosis of Cashmere Goat Hair Follicle Stem Cells Through the P53 Signaling Pathway Animals · 2025
    2. Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice Food frontiers · 2023
    3. Bioactive glass 1393 promotes angiogenesis and accelerates wound healing through ROS/P53/MMP9 signaling pathway Regenerative Therapy · 2024 · 8 citations
    4. Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation 2012
    5. Bioassay-guided isolation of two antiproliferative metabolites from Pterocarpus indicus Willd. against TGF-β-induced prostate stromal cells (WPMY-1) proliferation via PI3K/AKT signaling pathway Frontiers in Pharmacology · 2024 · 3 citations
    6. Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage Frontiers in Cell and Developmental Biology · 2020 · 33 citations
    7. 1339 Casein kinase 1 inhibition in keratinocytes enhances the migration of melanocyte precursors in the hair follicle via KitL/c-Kit signaling pathway Journal of Investigative Dermatology · 2023
    8. CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling Journal of Cellular and Molecular Medicine · 2018 · 28 citations
    9. Identification of blood microRNA alterations in patients with severe active alopecia areata Journal of Cellular Biochemistry · 2019 · 15 citations
    10. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris) Scientific reports · 2020 · 2 citations
    11. [Proteomics-based screening of differentially expressed proteins in skin of Chinese merino fine sheep (JunKen type) of different gender]. PubMed · 2022 · 1 citations
    12. Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair Annals of Dermatology · 2024
    13. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (<i>Atelerix albiventris</i>) bioRxiv (Cold Spring Harbor Laboratory) · 2020
    14. Molecular Regulation of Melanocyte Senescence Pigment Cell Research · 2002 · 85 citations
    15. Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    16. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues The Journal of Physiology · 2015 · 8 citations
    17. Understanding Cancer Cells of Origin in Cutaneous Tumors Elsevier eBooks · 2016 · 1 citations
    18. Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    19. Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    20. Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita Science Advances · 2025 · 3 citations
    21. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000 · 380 citations
    22. Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK / STAT1 signaling pathway FEBS Open Bio · 2025
    23. SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling Journal of Investigative Dermatology · 2024 · 4 citations
    24. Curcumin and cancer biology: Focusing regulatory effects in different signalling pathways Phytotherapy Research · 2021 · 27 citations
    25. Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    26. Epimorphic regeneration in mice is p53-independent Cell Cycle · 2010 · 20 citations
    27. Molecular mechanisms of viral oncogenesis in humans Nature Reviews Microbiology · 2018 · 141 citations
    28. Wnt4 is crucial for cardiac repair by regulating mesenchymal-endothelial transition via the phospho-JNK/JNK Theranostics · 2022 · 11 citations
    29. Transcriptomic characterization of Lonrf1 at the single-cell level under pathophysiological conditions The Journal of Biochemistry · 2023 · 7 citations
    30. Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review) Molecular Medicine Reports · 2021 · 18 citations