Epigallocatechin-3-Gallate Inhibits Paclitaxel-Induced Apoptosis Through the Alteration of MicroRNA Expression in Human Dermal Papilla Cells

    January 2018 in “ Biomedical dermatology ”
    Sang‐Goo Shin, Hwa Jun, Karam Kim, In‐Sook An, Kyung-Yun Kim, Jung-Eun Ku, Sun-Hee Jeong, Sungkwan An
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    Studysummary This study found that epigallocatechin-3-gallate (EGCG) may reduce paclitaxel-induced apoptosis in human dermal papilla cells by regulating microRNA expression related to apoptosis and cell proliferation. Our plain-language summary of this paper — not a Tressless recommendation.
    In the 2018 study by Shin et al., the researchers found that Epigallocatechin-3-gallate (EGCG), a component of green tea extract, could promote cell survival and inhibit apoptosis in human dermal papilla (HDP) cells that were exposed to paclitaxel, a chemotherapy drug known to cause hair loss. EGCG's protective effect was dose-dependent, and fluorescence-activated cell sorting (FACS) analysis confirmed its anti-apoptotic properties. Additionally, microRNA (miRNA) microarray analysis revealed that EGCG altered the expression of 48 miRNAs in paclitaxel-treated HDP cells, which are involved in the regulation of genes associated with apoptosis and cell proliferation, and related to signaling pathways like MAPK and Wnt. The study did not specify the number of cells or participants involved.
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