Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair

October 2024 in “ Annals of Dermatology ”

Seung‐Won Jung, Longquan Pi, Jae Joon Jeon, You Hyun Kim, Solam Lee, Won‐Soo Lee

Korean Red Ginseng ginsenoside G-Rb1 oxidative stress reactive oxygen species apoptosis follicular keratinocytes anagen stage telogen stage p53 signaling pathway Bax/Bcl2 signaling pathway KRG ROS FKCs

Studysummary In this in vitro study, red ginseng extract and its main ginsenoside, G-Rb1, were found to protect human hair follicular keratinocytes from oxidative damage, preventing apoptosis, promoting hair growth, and modulating hair cycle transitions by influencing specific cellular signaling pathways. Our plain-language summary of this paper — not a Tressless recommendation.

The study explored the protective effects of Korean Red Ginseng (KRG) and its main ginsenoside, G-Rb1, on human hair follicles against oxidative stress-induced damage. Using an in vitro organ model, it was found that KRG and G-Rb1 significantly reduced reactive oxygen species (ROS) production and apoptosis in follicular keratinocytes (FKCs), alleviating hair growth inhibition and preventing the transition from the anagen to the telogen stage. These protective effects were associated with the modulation of p53 and Bax/Bcl2 signaling pathways. The findings suggest that KRG and G-Rb1 can mitigate oxidative damage, promote hair growth, and maintain healthy hair cycles, indicating their potential in developing treatments for hair loss.

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