The Genetic Landscape of Androgenetic Alopecia: Current Knowledge and Future Perspectives

    January 2026 in “ Biology ”
    Aakar Gupta, Daniel J. Dennis, Vasiliki Economopoulos, Vincent Piguet
    Studysummary This review discusses the complex genetic factors contributing to androgenetic alopecia, highlighting the variability in genetic risk across different populations and the emerging understanding of personalized treatment strategies, but reports no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 70

    1. 26-SNP Panel Aids Guiding Androgenetic Alopecia Therapy and Provides Insight into Mechanisms of Action Cosmetics · 2025
    2. Progenitor Cell Dynamics in Androgenetic Alopecia: Insights from Spatially Resolved Transcriptomics International Journal of Molecular Sciences · 2025
    3. Revolutionary Approaches to Hair Regrowth: Follicle Neogenesis, Wnt/β-Catenin Signaling, and Emerging Therapies Cells · 2025
    4. Hair Transplantation: State of the Art Dermatologic Surgery · 2025
    5. Uncovering the Genetic Architecture and Evolutionary Roots of Androgenetic Alopecia in African Men Human Genetics and Genomics Advances · 2025
    6. Botulinum Toxin in the Treatment of Hair and Scalp Disorders: Current Evidence and Clinical Applications Toxins · 2025
    7. Epidemiological Landscape of Androgenetic Alopecia in the US: An All of Us Cross-Sectional Study PLoS ONE · 2025
    8. Genetic Variants and Lifestyle Factors in Androgenetic Alopecia Patients: A Case-Control Study of Single Nucleotide Polymorphisms and Their Contribution to Baldness Risk Nutrients · 2025
    9. Low-Level Laser And LED Therapy In Alopecia: A Systematic Review And Meta-Analysis Dermatologic Surgery · 2024
    10. Association Study Reveals a Susceptibility Locus With Male Pattern Baldness in the Han Chinese Population Frontiers in Genetics · 2024
    11. Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field Stem Cell Research & Therapy · 2024
    12. Genetic Differences Between Male and Female Pattern Hair Loss in a Korean Population Life · 2024
    13. Hair Follicle Sulfotransferase Activity and Effectiveness of Oral Minoxidil in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2024
    14. Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives Computational and Structural Biotechnology Journal · 2024
    15. Safety of Antiandrogens for the Treatment of Female Androgenetic Alopecia with Respect to Gynecologic Malignancies Journal of clinical medicine · 2024
    16. Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    17. Prioritizing Susceptibility Genes for the Prognosis of Male-Pattern Baldness With Transcriptome-Wide Association Study Human genomics · 2024
    18. Utilizing SNP Association Analysis as a Prospective Approach for Personalizing Androgenetic Alopecia Treatment Dermatology and therapy (Internet) · 2024
    19. The Role of Platelet-Rich Plasma in Androgenetic Alopecia: A Systematic Review Journal of Cosmetic Dermatology · 2024
    20. Efficacy of Topical Minoxidil and Finasteride Association Compared to Monotherapy in Men With Androgenetic Alopecia: A Prospective, Randomized, Controlled, Assessor-Blinded, 3-Arm, Pilot Trial Journal of Cosmetic Dermatology · 2023
    21. Analysis of 72,469 UK Biobank Exomes Links Rare Variants to Male-Pattern Hair Loss Nature Communications · 2023
    22. Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Identify Gene-Regulatory Programs and Critical Cell Types for Hair and Skin Diseases Nature Genetics · 2023
    23. Androgenetic Alopecia: An Update JAAD International · 2023
    24. Female Pattern Hair Loss: An Overview with Focus on the Genetics Genes · 2023
    25. Androgenetic Alopecia: Therapy Update Drugs · 2023
    26. Chronic Telogen Effluvium: Is It a Distinct Condition? A Systematic Review American Journal of Clinical Dermatology · 2023
    27. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    28. Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways British Journal of Dermatology · 2022
    29. Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2022
    30. The First Broad Replication Study of SNPs and a Pilot Genome-Wide Association Study for Androgenetic Alopecia in Asian Populations Journal of Cosmetic Dermatology · 2022
    31. Single-Cell Transcriptomics Reveals Lineage Trajectory of Human Scalp Hair Follicle and Informs Mechanisms of Hair Graying Cell discovery · 2022
    32. Comparison Between 5% Minoxidil Plus 2% Flutamide Solution vs. 5% Minoxidil Solution in the Treatment of Androgenetic Alopecia Journal of Cosmetic Dermatology · 2022
    33. SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth Journal of Cosmetic Dermatology · 2021
    34. Sulfotransferase SULT1A1 Activity in Hair Follicle: A Prognostic Marker of Response to Minoxidil Treatment in Androgenetic Alopecia Postepy Dermatologii I Alergologii · 2020
    35. The Efficacy and Safety of Finasteride Combined with Topical Minoxidil for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Aesthetic Plastic Surgery · 2020
    36. The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis Clinical Interventions in Aging · 2019
    37. The Efficacy and Use of Finasteride in Women: A Systematic Review International Journal of Dermatology · 2019
    38. Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study American Journal of Clinical Dermatology · 2018
    39. Genetic and Molecular Aspects of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018
    40. GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk Nature Communications · 2017
    41. Genetics and Other Factors in the Etiology of Female Pattern Hair Loss Experimental Dermatology · 2017
    42. Androgenetic Alopecia: A Review Endocrine · 2017
    43. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    44. Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia Sexual Medicine · 2016
    45. Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness PLOS ONE · 2015
    46. A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long-Term Side Effects After Finasteride Discontinuation International Journal of Biological Markers · 2014
    47. Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil in the Treatment of Female Androgenetic Alopecia Dermatologic Therapy · 2014
    48. Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss Archives of Dermatological Research · 2013
    49. Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2013
    50. Female Pattern Hair Loss: A Review Article international journal of endocrinology and metabolism · 2013
    51. Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population PLOS ONE · 2013
    52. Evidence for a Polygenic Contribution to Androgenetic Alopecia British Journal of Dermatology · 2013
    53. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    54. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    55. Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss British Journal of Dermatology · 2012
    56. Characteristics of Androgenetic Alopecia in Asian Populations Annals of Dermatology · 2012
    57. Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness British Journal of Dermatology · 2011
    58. Androgen Receptor Gene Polymorphisms and Risk for Androgenetic Alopecia: A Meta-Analysis Clinical and Experimental Dermatology · 2011
    59. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    60. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    61. Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26 American Journal of Human Genetics · 2008
    62. Androgenetic Alopecia: Clinical Features, Classification, and Treatments Endocrinology and Metabolism Clinics of North America · 2007
    63. 5α-Reductase Type 2 Gene Variant Associations with Prostate Cancer Risk, Circulating Hormone Levels, and Androgenetic Alopecia International Journal of Cancer · 2006
    64. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    65. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    66. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    67. Analysis of Genetic Polymorphisms of Steroid 5α-Reductase Type 1 and 2 Genes in Korean Men with Androgenetic Alopecia Journal of Dermatological Science · 2003
    68. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    69. Teloptosis: A Turning Point in Hair Shedding Biorhythms Dermatology · 2001
    70. The Biology of Hair Follicles The New England Journal of Medicine · 1999