Association Study Reveals a Susceptibility Locus With Male Pattern Baldness in the Han Chinese Population

September 2024 in “ Frontiers in Genetics ”

Li Yang, Huang He, Bo Liang, Feng-Li Xiao, Fusheng Zhou, Xiaodong Zheng, Sen Yang, Xuejun Zhang

male pattern baldness SNP rs13405699 2q31.1 CDCA7 SP3 TGF-β signaling pathway apoptosis MPB single nucleotide polymorphism transforming growth factor beta

TLDR A specific genetic marker is linked to male pattern baldness in Han Chinese men.

This study on Han Chinese men identifies the SNP rs13405699 at 2q31.1 as significantly associated with male pattern baldness (MPB), with a p-value of 4.84 × 10−5 and an odds ratio of 1.37, suggesting a potential genetic locus for MPB susceptibility in this population. The study involved 499 cases and 1,489 controls, and highlights the importance of considering ethnic-specific genetic factors in MPB research. The SNP is located near genes CDCA7 and SP3, which may influence MPB through the TGF-β signaling pathway and apoptosis. The study calls for further research with larger sample sizes to confirm these findings.

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