Characterization of X-Linked SNP Genotypic Variation in Globally Distributed Human Populations

    January 2010 in “ GenomeBiology.com (London. Print) ”
    Amanda M. Casto, Jun Z. Li, Devin Absher, R Myers, Sohini Ramachandran, Marcus W. Feldman
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    TLDR The research concluded that selection significantly shaped the genetic variation of the X chromosome, with certain regions affected by past selective events.
    The study analyzed 16,297 X-linked SNPs from the CEPH human genome diversity project and found greater differentiation on the X chromosome between human populations compared to autosomes, suggesting the influence of selective sweeps. Two regions on the X chromosome were identified as outliers, indicating past selection influences. The study also noted that demographic events like bottlenecks or migration patterns could have influenced genetic variation. Using 3 million SNPs from HapMap samples, the research found evidence of selection on the X chromosome, particularly in genes associated with diseases and traits like androgenic alopecia. The study concluded that selection has played a significant role in shaping X chromosome genetic variation and that geographically diverse samples are crucial for identifying genomic targets of selection.
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