TLDR The research concluded that selection significantly shaped the genetic variation of the X chromosome, with certain regions affected by past selective events.
The study analyzed 16,297 X-linked SNPs from the CEPH human genome diversity project and found greater differentiation on the X chromosome between human populations compared to autosomes, suggesting the influence of selective sweeps. Two regions on the X chromosome were identified as outliers, indicating past selection influences. The study also noted that demographic events like bottlenecks or migration patterns could have influenced genetic variation. Using 3 million SNPs from HapMap samples, the research found evidence of selection on the X chromosome, particularly in genes associated with diseases and traits like androgenic alopecia. The study concluded that selection has played a significant role in shaping X chromosome genetic variation and that geographically diverse samples are crucial for identifying genomic targets of selection.
82 citations,
September 2008 in “Journal of Investigative Dermatology” EDA2R gene linked to hair loss.
195 citations,
July 2005 in “American Journal of Human Genetics” Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
4 citations,
December 2012 in “Human Biology” The most different genetic segment between Africans and East Asians is the EDA2R/AR region, with two main types influenced by population changes and natural selection, and linked to baldness.
1 citations,
January 2017 in “Evolutionary studies” Different human traits like skin color and hair type vary between populations due to genetic adaptations to the environment.
27 citations,
April 2020 in “Molecular Biology and Evolution” Ancient Chinese goats evolved cashmere-producing traits due to selective breeding, particularly in genes affecting hair growth.
2 citations,
April 2022 in “Genes” The study found that the hair loss condition in Cesky Fousek dogs is influenced by multiple genes affecting skin and muscle structure, fat metabolism, and immunity.
47 citations,
August 2014 in “The Journal of Clinical Endocrinology and Metabolism” The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.
