Comparison Between 5% Minoxidil Plus 2% Flutamide Solution vs. 5% Minoxidil Solution in the Treatment of Androgenetic Alopecia

    February 2022 in “ Journal of Cosmetic Dermatology ”
    Gita Faghihi, Fariba Iraji, Amir Hossein Siadat, Mina Saber, Minoo Jelvan, Maedeh Sadat Hoseyni
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    TLDR Using both minoxidil and flutamide together is more effective for treating hair loss than using minoxidil alone.
    The study "Comparison between “5% minoxidil plus 2% flutamide” solution vs. “5% minoxidil” solution in the treatment of androgenetic alopecia" was a randomized, double-blinded clinical trial involving 40 patients with androgenetic alopecia. The patients were treated with either topical minoxidil or a combination of topical flutamide and minoxidil for 6 months. The results showed that the combination of flutamide and minoxidil was significantly more effective than minoxidil alone in terms of hair density, hair thickness, and patient satisfaction (p < 0.05). The study concluded that a topical hydroalcoholic solution of flutamide plus minoxidil may be a promising treatment for androgenetic alopecia, but recommended more prolonged studies with a higher number of patients for better evaluation.
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