Prioritizing Susceptibility Genes for the Prognosis of Male-Pattern Baldness With Transcriptome-Wide Association Study

    April 2024 in “ Human genomics
    Eun‐Young Choi, Jaeseung Song, Yubin Lee, Yun Hee Jeong, Wonhee Jang
    Image of study
    TLDR Identified genes linked to male-pattern baldness may help develop new treatments.
    This study on male-pattern baldness (MPB) used a transcriptome-wide association study (TWAS) to identify genetic associations and potential causality genes for different MPB types, analyzing data from 176,380 individuals of European ancestry. The study identified 10, 11, and 54 putative causality genes for MPB types 2, 3, and 4, respectively. Tissue-specific enrichment analysis revealed significant associations in various tissues, including adipose, blood/immune, and musculoskeletal/connective tissues. Functional enrichment and phenome-wide association studies (PheWAS) explored biological processes and traits linked to MPB-associated genes. The study also identified potential drug candidates, such as curcumin and succinic acid, for treating MPB, providing new insights into the genetic mechanisms and potential therapeutic targets for MPB.
    Discuss this study in the Community →

    Research cited in this study

    33 / 33 results

    Related Community Posts Join

    6 / 1000+ results

      community Diagnosed with MPB at 16 (Male)

      in Treatment  54 upvotes 6 months ago
      A 16-year-old diagnosed with male pattern baldness (MPB) was prescribed hair vitamins, vitamin D, a non-ketoconazole shampoo, and redenysl + serum, with a suggestion for GFC or IHRF treatments. Some users recommended minoxidil, ketoconazole, and derma stamping, while others advised against certain treatments until the age of 18.

      community The Hormonal Profile of MPB/AGA

      in Research/Science  9 upvotes 3 years ago
      Men with early male pattern baldness (MPB) may have hormonal abnormalities similar to those in women with PCOS. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

      community Treating MPB while dealing with seborrheic dermatitis?

      in Treatment  8 upvotes 4 months ago
      The user is seeking advice on treating male pattern baldness (MPB) while dealing with seborrheic dermatitis, specifically asking about the use of finasteride (Fin) and minoxidil (Min). They are concerned about side effects and are looking for recommendations to improve overall hair thickness, especially on the crown.

      community Going to try and reverse MPB naturally.

      in Treatment  55 upvotes 2 years ago
      A user is trying to reverse male pattern baldness (MPB) naturally by taking high doses of Vitamin D, improving diet, exercising, reducing stress, and other lifestyle changes, but plans to use finasteride if no results are seen in 60 days. Other users are skeptical, advising medical treatments like finasteride and warning against potential vitamin D overdose and the ineffectiveness of natural remedies for genetic hair loss.

    Similar Research

    5 / 1000+ results