Analysis of Cytokines and ATP in Plucked Hair Follicles

January 2021 in “ Bulletin of Experimental Biology and Medicine ”

Elena V. Mikhalchik, О. В. Морозова, T. V. Tsimbalenko, З. Ф. Хараева, Н. Г. Балабушевич, V. A. Lipatova, Aida Gadzhigoroeva

ATP IL-6 IL-10 androgenetic alopecia hair follicles hair growth factors ELISA RT-PCR adenosine triphosphate interleukin-6 interleukin-10 pattern hair loss enzyme-linked immunosorbent assay reverse transcription polymerase chain reaction

TLDR ATP and IL-10 levels in hair follicles relate to follicle length and hair growth, with differences in alopecia patients.

The study analyzed ATP, IL-6, and IL-10 concentrations in plucked hair follicles from healthy individuals and patients with androgenetic alopecia. It found that ATP and IL-10 levels were related to follicle length and hair growth factors, with IL-10 levels higher in shorter follicles (<1 mm) and ATP levels higher in longer follicles (>2 mm) in alopecia patients. ATP levels correlated with cell damage, and IL-6 levels did not vary with follicle length. The study used ELISA and RT-PCR to confirm moderate gene expression levels of IL-6 and IL-10.

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