Prioritizing Susceptibility Genes for the Prognosis of Male-Pattern Baldness with Transcriptome-Wide Association Study

January 2024 in “ Research Square (Research Square) ”

Eun‐Young Choi, Jaeseung Song, Yubin Lee, Yun Hee Jeong, Wonhee Jang

male-pattern baldness MPB susceptibility genes gene expression genotype data tissue-specific enrichment analysis genotype-tissue expression context-specific genetics putative causality genes drug candidates

TLDR The research identified genes linked to male-pattern baldness and potential drug targets for treatment.

The study "Prioritizing Susceptibility Genes for the Prognosis of Male-pattern Baldness with Transcriptome-wide Association Study" conducted an integrative analysis of gene expression and genotype data to identify susceptibility genes for male-pattern baldness (MPB). The researchers used tissue-specific enrichment analysis and single-tissue panels from genotype-tissue expression version 8, as well as cross-tissue panels from context-specific genetics. They identified 52, 75, and 144 MPB associations for type 2, type 3, and type 4 MPB respectively, and 10, 11, and 54 putative causality genes for the same types. The study also identified potential drug candidates connected to MPB-associated genes, which could help in developing treatments for MPB.

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