Regenerative Strategies for Androgenetic Alopecia: Evidence, Mechanisms, and Translational Pathways

    January 2026 in “ Cosmetics
    Rimma Laufer Britva, Amos Gilhar
    TLDR New regenerative treatments show promise in improving hair growth for androgenetic alopecia.
    The document reviews regenerative strategies for androgenetic alopecia (AGA), emphasizing a shift from traditional treatments to those aiming to restore hair follicle function. Emerging therapies, such as stem cell-derived conditioned media, exosomes, and autologous cell-based treatments, show promise in activating signaling pathways like Wnt/β-catenin, enhancing angiogenesis, and promoting dermal papilla cell survival, leading to improved hair density and thickness. Adjunctive methods like microneedling and platelet-rich plasma (PRP) support follicular regeneration, though PRP shows variable efficacy. Machine learning and robotic platforms enhance diagnostic and surgical precision. Despite these advances, challenges remain in standardizing protocols and achieving large-scale clinical translation. Future progress will depend on long-term clinical trials to establish reliable regenerative approaches for sustainable follicle renewal in cosmetic dermatology.
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