Stem Cell-Derived Conditioned Medium for Alopecia: A Systematic Review and Meta-Analysis

January 2024 in “ Journal of plastic, reconstructive & aesthetic surgery ”

Wei-Ying Chien, Huimin Huang, Yi-No Kang, Kee Hsin Chen, Wei-Ying Chien

stem cell–derived conditioned medium alopecia hair density hair thickness microneedling injection topical application stem cell CM hair loss hair growth

TLDR Stem cell-derived conditioned medium is effective in improving hair density and thickness for alopecia treatment.

This systematic review and meta-analysis of 10 clinical trials with 221 participants found that stem cell–derived conditioned medium (CM) significantly increased hair density (MD: 14.93, 95% CI: 10.20–19.67, p < 0.0001) and hair thickness (MD: 18.67, 95% CI: 2.75–34.59, p < 0.0001) in alopecia patients. Longer treatment durations led to greater improvements (p = 0.02). Analysis of three RCTs also showed significant results for hair density (MD: 9.23, 95% CI: 1.79–16.68, p < 0.00001). The study concluded that stem cell–derived CM is an effective treatment for alopecia, with no significant difference between application methods.

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