Enhancing Hair Growth Through Phytochemicals: Mechanisms, Supporting Evidence, and Future Directions

The study explores the potential of phytochemicals in promoting hair growth by examining their effects on hair follicle physiology and growth cycles. Key findings indicate that certain phytochemicals, such as Malva verticillata, Elephantopus scaber L., Sophora flavescens, and Epigallocatechin-3-gallate, stimulate hair follicles and promote keratinocyte proliferation through various pathways, including the Wnt/β-catenin pathway and AKT signaling. These compounds also elevate growth factors like IGF-1 and VEGF, which are crucial for hair growth. Despite their potential as natural and safer alternatives to conventional drugs, challenges remain in improving the bioavailability and standardization of these formulations. Further research is necessary to optimize these aspects for effective therapeutic use.