Hormonal and Genetic Etiology of Male Androgenetic Alopecia

Impaired autophagy may cause hair loss by triggering early catagen.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.

Gene differences found in hair follicles linked to male baldness.

Prostanoids, like prostaglandins and thromboxane A2, can both enhance and inhibit hair growth, and understanding their effects could help treat hair disorders.

Genomic approach finds new possible treatments for hair loss.

Stress can cause early aging in certain skin cells, leading to problems with hair growth.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Androgens prevent hair growth by changing Wnt signals in cells.

Methyl vanillate spray increases hair count and hair mass in women with hair loss.

Men with early hair loss have similar hormone levels to women with PCOS, possibly increasing risk of obesity and heart issues.

New genes found linked to balding, may help develop future treatments.

Prostaglandin D2 increases testosterone levels in skin cells through reactive oxygen species, not enzymes, which could lead to new hair loss treatments.

Different types of hair loss need specific treatments, and while many classification systems exist, each has its flaws; more research is needed to refine these systems and treatments.

Hair thickness matters more than density for baldness in Japanese men over 25.

Higher caspase-1 levels found in balding scalps; reducing it may help treat hair loss.

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

PGD2 stops hair growth and is higher in bald men with AGA.

G allele of AR Stul polymorphism linked to higher hair loss risk, especially in white people.

Lower growth factors linked to balding in androgenetic alopecia.

Men with hair loss have more DNA changes in back-of-head hair follicles, possibly protecting them from thinning.

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Two gene areas linked to male pattern baldness found, more research needed.

Alopecia common in teens, may indicate endocrine issue, minoxidil effective treatment.

Mice with human gene experienced hair loss when treated with DHT.

Baldness is more common in Chinese men than women, increasing with age, and is influenced by genetics.

Genetic marker rs12558842 strongly linked to male hair loss.

Aromatase gene variation may increase female hair loss risk.

58% of men aged 30-50 have hair loss, with severity increasing with age.

Sparse hairs below frontal hairline can indicate early male balding.

Chinese men have lower AGA rates than Caucasians, with type III vertex most common; family history is important.

Bald areas have lower cell growth, more DNA damage, and increased cell death.

EDA2R gene linked to hair loss.

SCF and c-Kit decrease in AGA hair follicles, possibly affecting hair pigmentation and growth.

Hair loss gene found on chromosome 3q26.

Mast cells might contribute to hair loss by causing skin thickening.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

AR polyglycine repeat doesn't cause baldness.

Androgen hormones cause hair follicle scarring in hair loss, and finasteride helps reduce it.

Hair loss common in Australia; men affected earlier, more often than Asians; women less concerned.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

AGA can occur in children with family history; early diagnosis and treatment important.

Hair loss increases with age; alcohol raises risk, more female partners lowers it.

Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

Hair from balding and non-balding areas regrows similarly on mice.

Gene differences may affect baldness treatment response in Korean men.

Hair loss occurs due to fewer papillary cells, smaller follicles, and shorter growth phases.

AGA more common in men, Koreans have lower rates and unique patterns.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

FPHL affects hair density and diameter, causing visible hair loss in older women.

Early hair loss may indicate risk of insulin resistance.

Mutation in hairless gene may increase hair loss risk.

Hair loss common in Norwegian men, affecting self-esteem and life quality.

Gene linked to common hair loss found, may lead to new treatments.

Stump-tailed macaque best for researching hair loss causes and treatments.

Early onset hair loss linked to genetics and androgen levels.

Hair loss is more common in men aged 18-49 and increases with age.

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

Hair loss in men is common, treatable, but not curable.

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Tamoxifen caused hair loss in a 52-year-old woman.

Too much androgen can cause hair loss; finasteride may help.

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.

EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.

Men with hair loss have lower SHBG and higher saliva testosterone levels, suggesting increased androgen activity.

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.