Emerging Biomedical Engineering Strategies for Hair Follicle Regeneration

    July 2025 in “ Bioactive Materials
    Xinyue Cao, Minhui Lu, Ning Li, Lijun Cai, Yu Wang, Yuanjin Zhao
    TLDR New engineering methods show promise for regenerating hair follicles using stem cells and advanced technologies.
    The review article explores the latest advancements in biomedical engineering strategies for hair follicle regeneration, emphasizing a shift from traditional replacement therapies to functional reconstruction. It highlights interdisciplinary approaches, including stem cell technology, tissue engineering, and modern engineering methods, to achieve hair follicle regeneration. The document discusses in vivo strategies like cell transplantation and biomaterial delivery, and in vitro successes with hair follicle organoids for hair growth and drug screening applications. It also addresses technical limitations and future prospects, providing a theoretical framework for future innovations in hair regenerative medicine. Key strategies include the use of 3D bioprinting, microfluidic devices, and biomimetic molds, as well as the integration of traditional Chinese medicine with modern bioengineering. These innovative approaches offer promising avenues for treating conditions like androgenetic alopecia and alopecia areata, though further studies are needed to optimize their applications.
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