Intrinsic and Extrinsic Factors Associated with Hair Graying and Therapeutic Potential of Plant Extracts and Phytochemicals

    August 2024 in “ Applied Sciences ”
    Yong Chool Boo
    Studysummary This review explored the causes of hair graying and evaluated how plant-derived extracts and phytochemicals might alleviate it, noting that certain compounds showed potential in enhancing melanocyte function, reducing oxidative stress, and influencing stress-related pathways based on experimental evidence.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 78

    1. Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets Molecules/Molecules online/Molecules annual · 2024
    2. Fractal Pattern in the Premature Graying of Hair: A Case Report Curēus · 2024
    3. Melanocyte Stem Cells in the Skin: Origin, Biological Characteristics, Homeostatic Maintenance and Therapeutic Potential Clinical and Translational Medicine · 2024
    4. Acitretin-Induced Repigmentation of Gray Hair: A Case Report Curēus · 2024
    5. Two Case Studies of Persistent White Hair Regrowth After Alopecia Areata Turning Pigmented Following Treatment Journal of Cosmetic Dermatology · 2024
    6. Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence GeroScience · 2024
    7. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    8. Human Hair Graying Revisited: Principles, Misconceptions, And Key Research Frontiers Journal of Investigative Dermatology · 2023
    9. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    10. Loss Of Dicer In Newborn Melanocytes Leads To Premature Hair Graying And Changes In Integrin Expression ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    11. Gynostemma Pentaphyllum Makino Extract Induces Hair Growth And Exhibits An Anti-Graying Effect Via Multiple Mechanisms Journal of Cosmetic Dermatology · 2023
    12. Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss Journal of Clinical Medicine · 2023
    13. Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress International journal of biological sciences · 2023
    14. Reversal of Premature Hair Graying Treated with a Topical Formulation Containing α-Melanocyte-Stimulating Hormone Agonist (Greyverse Solution 2%) International journal of trichology · 2022
    15. Single-Cell Transcriptomics Reveals Lineage Trajectory of Human Scalp Hair Follicle and Informs Mechanisms of Hair Graying Cell discovery · 2022
    16. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    17. Hair Graying Regulators Beyond Hair Follicle Frontiers in physiology · 2022
    18. Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy Cells · 2021
    19. Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging Frontiers in Cell and Developmental Biology · 2021
    20. The Anti-Apoptotic Bcl-2 Protein Regulates Hair Follicle Stem Cell Function EMBO Reports · 2021
    21. Effects of UV-Induced Photoaging on the Hair Follicle Cycle of C57BL6/J Mice Clinical, cosmetic and investigational dermatology · 2021
    22. Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp Scientific reports · 2020
    23. Epidemiological and Biochemical Factors (Serum Ferritin and Vitamin D) Associated with Premature Hair Graying in the Egyptian Population Journal of Cosmetic Dermatology · 2020
    24. The biology of human hair greying Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2020
    25. Exploring the Possibility of Predicting Human Head Hair Greying from DNA Using Whole-Exome and Targeted NGS Data BMC Genomics · 2020
    26. Premature Graying of Hair: Risk Factors, Co-Morbid Conditions, Pharmacotherapy and Reversal—A Systematic Review and Meta-Analysis Dermatologic therapy · 2020
    27. Topical RT1640 Treatment Effectively Reverses Gray Hair and Stem Cell Loss in a Mouse Model of Radiation-Induced Canities Pigment cell & melanoma research · 2020
    28. Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies Experimental Dermatology · 2020
    29. Clinical and Epidemiological Characteristics and Associated Factors of Hair Graying: A Population-Based, Cross-Sectional Study in Turkey Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2020
    30. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    31. Medication-Induced Repigmentation of Gray Hair: A Systematic Review Skin appendage disorders · 2019
    32. Serum Levels of Lead and Selenium in Patients with Premature Graying of the Hair Journal of cosmetic dermatology · 2019
    33. Human Pollution Exposure Correlates With Accelerated Ultrastructural Degradation of Hair Fibers Proceedings of the National Academy of Sciences of the United States of America · 2019
    34. Impact of Premature Greying of Hair on Socio-Cultural Adjustment and Self-Esteem Among Medical Undergraduates in Foundation University, Islamabad Curēus · 2019
    35. Therapeutics of Premature Hair Graying: A Long Journey Ahead Journal of cosmetic dermatology · 2019
    36. Case Report on Premature Hair Graying Treated with Melitane 5% and Oral Hair Supplements Indian Journal of Pharmacology · 2019
    37. Relationship Between Diet, Atopy, Family History, and Premature Hair Graying Journal of Cosmetic Dermatology · 2018
    38. Relationship Between Trace Elements and Premature Hair Graying International Journal of Trichology · 2018
    39. Association of Epidemiological and Biochemical Factors with Premature Graying of Hair: A Case-Control Study International journal of trichology · 2018
    40. Three Streams for the Mechanism of Hair Graying Annals of dermatology/Annals of Dermatology · 2018
    41. Association Between Premature Hair Greying and Metabolic Risk Factors: A Cross-Sectional Study Acta dermato-venereologica · 2018
    42. Androgenic Alopecia, Premature Graying, and Hair Thinning as Independent Predictors of Coronary Artery Disease in Young Asian Males Cardiovascular endocrinology · 2017
    43. Wnt/β-Catenin Signaling Promotes Aging-Associated Hair Graying in Mice Oncotarget · 2017
    44. Aging in Hair Follicle Stem Cells and Niche Microenvironment The Journal of Dermatology · 2017
    45. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin, and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases DOAJ (DOAJ: Directory of Open Access Journals) · 2017
    46. Risk Factors for Premature Hair Graying in Young Turkish Adults Pediatric Dermatology · 2016
    47. A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features Nature Communications · 2016
    48. Psychiatric Shades of Grey: Mirtazapine-Induced Hair Discoloration and Hair Loss Irish journal of psychological medicine · 2016
    49. Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments Oxidative medicine and cellular longevity · 2016
    50. Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles Cells tissues organs · 2016
    51. Factors Associated With Premature Hair Graying in a Young Indian Population International journal of trichology · 2016
    52. A Case of Premature Hair Graying Treated with Ferrous Sulfate Annals of dermatology/Annals of Dermatology · 2016
    53. Hair Growth Promotion Activity and Its Mechanism of Polygonum Multiflorum Evidence-based Complementary and Alternative Medicine · 2015
    54. Association of Premature Hair Graying with Family History, Smoking, and Obesity: A Cross-Sectional Study Journal of The American Academy of Dermatology · 2014
    55. Age-Related Hair Changes in Men: Mechanisms and Management of Alopecia and Graying Maturitas · 2014
    56. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    57. Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors PLOS ONE · 2014
    58. Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress International Journal of Cosmetic Science · 2013
    59. Keratinocyte Stem Cells but Not Melanocyte Stem Cells Are the Primary Target for Radiation-Induced Hair Graying Journal of Investigative Dermatology · 2013
    60. The Pattern of Hair Dyeing in Koreans With Gray Hair Annals of Dermatology · 2013
    61. Premature Graying of Hair: Causes, Associations, and Treatments Indian Journal of Dermatology, Venereology and Leprology · 2013
    62. Epidemiological and Investigative Study of Premature Graying of Hair in Higher Secondary and Pre-University School Children International Journal of Trichology · 2013
    63. The Degree of Premature Hair Graying as an Independent Risk Marker for Coronary Artery Disease: A Predictor of Biological Age Rather Than Chronological Age The Anatolian journal of cardiology · 2012
    64. Hair Repigmentation Associated with the Use of Lenalidomide: Graying May Not Be an Irreversible Process Journal of oncology pharmacy practice · 2012
    65. Serum Iron, Zinc, and Copper Concentration in Premature Graying of Hair Biological trace element research · 2011
    66. Hair Greying Is Associated With Active Hair Growth British Journal of Dermatology · 2011
    67. Aging Processes Influence Keratin and KAP Expression in Human Hair Follicles Experimental Dermatology · 2011
    68. Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice Journal of Ethnopharmacology · 2011
    69. Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile Involving Catalase ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    70. Senile Hair Graying: H2O2-Mediated Oxidative Stress Affects Human Hair Color by Blunting Methionine Sulfoxide Repair The FASEB Journal · 2009
    71. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    72. Aging of the Hair Follicle Pigmentation System International journal of trichology · 2009
    73. Oxidative Stress in Aging of Hair International Journal of Trichology · 2009
    74. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    75. Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage ˜The œFASEB journal · 2006
    76. Melanocyte Stem Cell Maintenance and Hair Graying Cell · 2005
    77. Protective Effect of Superoxide Dismutase Against Hair Graying in a Mouse Model Photochemistry and Photobiology · 2004
    78. Human Essential Fatty Acid Deficiency Archives of Dermatology · 1977