August 2024 in “Applied Sciences” This review explored the causes of hair graying and evaluated how plant-derived extracts and phytochemicals might alleviate it, noting that certain compounds showed potential in enhancing melanocyte function, reducing oxidative stress, and influencing stress-related pathways based on experimental evidence.
April 2017 in “Journal of Dermatological Science” In this study, researchers found that in adult mice, new hair follicles with pigmentation can regenerate from the epidermis after skin wounding, aided by melanocyte stem cells moving from nearby existing hair follicles.
April 2017 in “Journal of Dermatological Science” This study found that B cells have dual roles in tumor immunity, with regulatory B cells potentially hindering immune responses against tumors in the melanoma mouse model.
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August 2019 in “Biological & Pharmaceutical Bulletin” This study found that flavonoids with two hydroxyl groups in their B-ring, such as sterubin and luteolin, supported the regeneration of pigmented hair after skin injury, unlike those with one hydroxyl group.
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January 2023 in “International journal of biological sciences” This review discusses the mechanisms of hair repigmentation and reports no clinical results; the authors suggest further research into topical treatments for reversing gray hair.