Melanocyte Stem Cells in the Skin: Origin, Biological Characteristics, Homeostatic Maintenance and Therapeutic Potential

    May 2024 in “ Clinical and Translational Medicine ”
    Luling Huang, Yuzhi Zuo, Shuli Li, Chunying Li
    Studysummary This review discusses the origin, characteristics, and therapeutic potential of melanocyte stem cells in skin pigmentation disorders and reports no clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 28

    1. Melanocyte Stem Cells in the Skin: Origin, Biological Characteristics, Homeostatic Maintenance and Therapeutic Potential Clinical and Translational Medicine · 2024
    2. SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis Through p53/Stem Cell Factor/C-KIT Signaling Journal of Investigative Dermatology · 2024
    3. Incorporation of Hair Follicles in 3D Bioprinted Models of Human Skin Science Advances · 2023
    4. BMI1 Is Required for Melanocyte Stem Cell Maintenance and Hair Pigmentation Pigment Cell & Melanoma Research · 2023
    5. An Efficient, Non-Invasive Approach for In Vivo Sampling of Hair Follicles: Design and Applications in Monitoring DNA Damage and Aging Aging · 2021
    6. Melanocyte Progenitor Cells Reside in Human Subcutaneous Adipose Tissue PLoS ONE · 2021
    7. The biology of human hair greying Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2020
    8. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    9. A Novel Mouse Model Demonstrates That Oncogenic Melanocyte Stem Cells Engender Melanoma Resembling Human Disease Nature Communications · 2019
    10. CD34 Defines Melanocyte Stem Cell Subpopulations With Distinct Regenerative Properties PLOS genetics · 2019
    11. Therapeutic Potential of Patient iPSC-Derived Melanocytes in Autologous Transplantation Cell reports · 2019
    12. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    13. EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling Cell Reports · 2016
    14. Aging, Alopecia, and Stem Cells Science · 2016
    15. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    16. Stem Cells Applications In Regenerative Medicine And Disease Therapeutics International Journal of Cell Biology · 2016
    17. Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering Expert Opinion on Biological Therapy · 2013
    18. Dissecting the Bulge in Hair Regeneration Journal of Clinical Investigation · 2012
    19. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    20. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    21. Coexistence of Quiescent and Active Adult Stem Cells in Mammals Science · 2010
    22. The Chemokine SDF-1/CXCL12 Regulates the Migration of Melanocyte Progenitors in Mouse Hair Follicles Differentiation · 2009
    23. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    24. A Rare Repigmentation Pattern in a Vitiligo Patient: A Clue to an Epidermal Stem-Cell Reservoir of Melanocytes? Clinical and experimental dermatology · 2008
    25. Melanoblasts' Proper Location and Timed Differentiation Depend on Notch/RBP-J Signaling in Postnatal Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    26. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    27. Stem Cells and Their Niches Science · 2006
    28. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005

    Related research 3

    1. Casein Kinase 1 Inhibition in Keratinocytes Enhances the Migration of Melanocyte Precursors in the Hair Follicle via KitL/c-Kit Signaling Pathway Journal of Investigative Dermatology · 2023
    2. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    3. Functionally Distinct Melanocyte Populations Revealed by Reconstitution of Hair Follicles in Mice Pigment Cell & Melanoma Research · 2010