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Glossary Pigmentation Disorders

conditions affecting skin, hair, or eye color due to melanin abnormalities

Pigmentation disorders are conditions that affect the color of your skin, hair, or eyes due to abnormal melanin production. These disorders can result in patches of skin that are lighter (hypopigmentation) or darker (hyperpigmentation) than the surrounding areas, and can be caused by genetic factors, sun exposure, or underlying health issues.

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Research

5 / 1000+ results

research Photobiomodulation for Skin Pigmentation Disorders: A Dual-Function Treatment

2 citations , May 2023 in “Photobiomodulation, photomedicine, and laser surgery”

This editorial reviews how photobiomodulation therapy might effectively treat both hyperpigmentation and depigmentation skin disorders, but reports no new clinical results.

research Metabolic profiling by LC-DAD-MS, FTIR, NMR and CE-UV of polyphenols with potential against skin pigmentation disorder

November 2021 in “Natural product research”

This study observed that the aqueous extract of roasted Alocasia macrorrhizos tubers led to hair follicle repigmentation and reduced epidermal thickness in a murine model of Vitiligo.

research In Vitro Skin Models for Pigmentary Disorders: From Reconstructed Tissues to Skin-on-a-Chip Platforms

August 2026 in “Regenerative Biomaterials”

This review examines human-relevant in vitro models for studying pigmentation disorders, identifying both challenges and advancements in replicating human pigmentation processes and disease-specific pathology in vitro.

research Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation

60 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.

research Restoration of skin pigmentation after deep partial or full-thickness burn injury

37 citations , October 2017 in “Advanced drug delivery reviews”

This review explores the mechanisms of skin repigmentation and therapeutic strategies for pigmentation disorders following burn injuries, but it presents no new clinical results.

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Community Join

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community 1.5 years topical minox 0.5 ml twice (just temples) + 0.5 mg oral finasteride daily.

in Progress Pictures 664 upvotes 11 months ago

The user experienced hair regrowth and improved hair quality using topical minoxidil on temples and oral finasteride daily. They also noted thicker eyebrows and some side effects like minor erectile dysfunction.

community Gland treatment and Crude Oil Massage

7 years ago

Hair loss treatment involves gland treatment with iodine, liver extract, wild American ginseng, and black cohosh, along with crude oil scalp massage. The approach aims to stimulate hormones and improve blood circulation to promote hair growth.

community 2 % fucoidan significantly alleviated AGA symptoms, promoted hair growth, and increased hair density

21 upvotes 11 months ago

2% fucoidan alleviated AGA symptoms, promoted hair growth, and increased hair density in mice. Fucoidan is considered safe for humans as a supplement and topical skincare product, with potential therapeutic effects against AGA.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Making your own RT1640 in China

4 years ago

RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.

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Learn

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learn Overview

learn Stem Cell Factor

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
Who is a good candidate for scalp micropigmentation? Good candidates for scalp micropigmentation include anyone experiencing hair loss or thinning.
Is scalp micropigmentation safe? Providers describe scalp micropigmentation as low-risk when a trained practitioner uses sterile single-use equipment, but that is a provider claim rather than a regulatory finding: pigment allergy, infection and colour change are documented risks of cosmetic tattooing.
All 5 questions on Scalp Micropigmentation →

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Clinics

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70
Trichology
The Pharmacy for Hair Loss & Scalp Disorders, PLLC.Brentwood, TN · US

Experts

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36
SMP Specialist
Noelle Skin
Nice, France

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Noelle Skin