TLDR BMI1 is essential for preventing hair greying and maintaining hair color.
The study reveals that the epigenetic repressor BMI1 is essential for maintaining melanocyte stem cells (McSCs) and hair pigmentation in mice. Deletion of Bmi1 led to premature hair greying, loss of melanocyte lineage cells, and increased stress sensitivity. RNA sequencing showed that Bmi1 deletion upregulated Cdkn2a, increasing p16Ink4a and p19Arf expression, and downregulated oxidative stress-related enzymes Gsta1 and Gsta2. Treatment with the antioxidant N-acetyl cysteine partially rescued melanocyte expansion. The findings underscore BMI1's role in protecting McSCs from stress and maintaining hair pigmentation through both canonical and non-canonical pathways.
24 citations,
March 2018 in “Pigment Cell & Melanoma Research” The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.
260 citations,
June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
375 citations,
February 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
105 citations,
April 2005 in “Cell” Hair graying happens because certain cells aren't maintained properly.
January 2024 in “GeroScience” Using radiation to make mice's hair turn gray helps study and find ways to prevent or reverse hair graying.
36 citations,
September 2009 in “Journal of Cellular and Molecular Medicine” New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
25 citations,
November 2014 in “Ageing Research Reviews” Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.
85 citations,
July 2002 in “Pigment Cell Research” The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.
41 citations,
September 2012 in “Cellular and Molecular Life Sciences” MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.
