Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Diseases

    May 2023 in “Journal of Clinical Medicine
    Misaki Kinoshita‐Ise, Masafumi Fukuyama, Manabu Ohyama
    TLDR New understanding and treatments for hair loss are improving, but more research is needed.
    The document reviews recent advances in understanding the causes, diagnosis, and management of hair loss diseases. It emphasizes the importance of accurate diagnosis and disease severity assessment for effective treatment. New diagnostic systems and techniques, such as trichoscopy and hair pull tests, are discussed. The paper also highlights breakthroughs in hair follicle biology and immunology, which have led to a deeper understanding of hair loss diseases. It discusses the genetic and epidemiological analysis that has elucidated disease susceptibility for androgenetic alopecia (AGA) and female pattern hair loss (FPHL). The association between COVID-19 and hair loss, with telogen effluvium being the predominant pathomechanism, is also mentioned. The document reviews several treatment options, including oral 5-α reductase inhibitors, finasteride and dutasteride, minoxidil, Platelet-Rich Plasma (PRP) treatment, hormone-modulating therapies, hair transplantation, low-level laser therapy (LLLT), topical cetirizine, and autologous-cell-based therapy. The document concludes by stating that more research is needed to fully establish these and other treatments as therapeutic options for hair loss diseases.
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