Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia

October 2021 in “ JID innovations ”

Taylor A. Jamerson, C. Conover Talbot, Yemisi Dina, Crystal Aguh

Central Centrifugal Cicatricial Alopecia CCCA gene expression scalp upregulated genes

TLDR Uterine leiomyomas don't significantly change gene expression in the scalp of people with Central Centrifugal Cicatricial Alopecia.

The study investigated the effect of uterine leiomyomas (ULs) on the gene expression in the scalp of 16 patients with Central Centrifugal Cicatricial Alopecia (CCCA). After analyzing over 20,000 genes, the results indicated that ULs did not significantly impact the gene expression in the scalp of these patients. Only eight genes were upregulated with a fold change in expression >2 in patients with CCCA and ULs compared to those without ULs. The study concluded that there is no evidence of a causational or linked relationship between the increased prevalence of ULs and CCCA, suggesting that they likely occur independently. However, the study's conclusions are limited due to its small sample size and the use of whole-scalp tissue in the analysis.

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