Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia

October 2021 in “ JID innovations ”

Taylor A. Jamerson, C. Conover Talbot, Yemisi Dina, Crystal Aguh

Central Centrifugal Cicatricial Alopecia CCCA gene expression scalp upregulated genes

Studysummary This study found no significant gene expression differences in the lesional scalp of patients with central centrifugal cicatricial alopecia with and without a history of uterine leiomyomas.

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This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.

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This review discusses the evolution and ongoing debate about the causes of central centrifugal cicatricial alopecia in African American women, without presenting new clinical findings.

research Cicatricial Alopecia: Classification and Histopathology

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This review discusses histopathologic findings in diagnosing primary cicatricial alopecias and emphasizes the importance of correlating histology with clinical presentation for accurate diagnosis; it reports no new results.

research Central Scalp Alopecia Photographic Scale in African American Women

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This study developed and evaluated a photographic scale to assess CCCA pattern and severity in African American women, finding it reproducible when used by investigators and participants.

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In this study, two novel clusters of keratin-associated protein genes on human chromosome 11 were analyzed, suggesting their products are crucial for hair formation due to preferential expression in hair roots.