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      learn Follistatin

      glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

      learn Estradiol

      an estrogen promoting hair regrowth more commonly used in women

      learn Minoxidil

      An essential vasodilator with some anti-androgenic effects, has excellent safety record

      learn Sulforaphane

      compound from cruciferous vegetables has some mild effects on DHT

    Research

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      community Any treatment not nuking systemic DHT levels?

      in Finasteride/Dutasteride  16 upvotes 5 days ago
      Hair loss treatments that avoid significantly lowering systemic DHT levels, focusing on topical options like dutasteride mesotherapy, minoxidil, and ketoconazole. The user is exploring alternatives like KX-826 and RU58841 due to concerns about hormone levels.

      community Hair loss research is a money grab

      in Chat  227 upvotes 3 months ago
      Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

      community Occipitalis Muscle Tension Theory

      in Treatment  8 upvotes 3 weeks ago
      Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.

      community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

      in Research/Science  125 upvotes 2 years ago
      The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.