Familial Frontal Fibrosing Alopecia

The document discussed Familial Frontal Fibrosing Alopecia (FFA), a condition characterized by progressive hair loss along the frontal hairline, predominantly affecting postmenopausal women. The study highlighted the genetic predisposition of FFA, noting that it often occurred in multiple family members, suggesting a hereditary component. The research included a review of clinical presentations, histopathological findings, and potential treatment options. The authors emphasized the importance of early diagnosis and intervention to manage symptoms and prevent further hair loss. The study underscored the need for further research to understand the underlying genetic mechanisms and to develop more effective treatments. The document reported a case of familial frontal fibrosing alopecia (FFA) involving three sisters, adding to the 24 previously documented familial cases, making it the 25th. The sisters, aged 59, 62, and 67, exhibited frontotemporal hairline recession and eyebrow loss, with one sister achieving disease control through treatment. The systematic review revealed that familial FFA predominantly affected females (88%) and was most commonly observed between sisters (56%) and mother-daughter pairs (32%). The median age of onset was 61 years, with disease duration ranging from 3 to 360 months. The review highlighted the need for further research into the genetic and environmental factors contributing to FFA.