Vitamin D Receptor Gene Polymorphism in Chronic Telogen Effluvium: A Case-Control Study

October 2019 in “ Clinical, Cosmetic and Investigational Dermatology ”

Iman Seleit, Ola Ahmed Bakry, Eman Badr, Ekram M. Hassan

Vitamin D receptor VDR gene polymorphism Cdx1 Taq1 chronic telogen effluvium TE hair follicle stem cell RNA stability hair growth

TLDR Certain gene variations in the Vitamin D receptor may increase the risk of chronic hair loss.

The study from 2019 examined the relationship between Vitamin D receptor (VDR) gene polymorphisms (Cdx1 and Taq1) and chronic telogen effluvium (TE), a type of hair loss. It included 30 female patients with chronic TE and 30 healthy controls. The study found that the CC genotype of Taq1 significantly increased the risk of chronic TE by 14.7 times, and the C allele by 3.1 times. Similarly, the GA genotype of Cdx1 was associated with a 6.3 times higher risk, and the A allele with a 3.8 times higher risk. These findings suggest that individuals with these specific VDR gene polymorphisms are at an increased risk of chronic TE due to the impact on hair follicle stem cell proliferation and RNA stability, which affects hair growth. The study was limited by its small sample size and focused only on chronic TE.

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