TLDR New hair loss treatments may include topical medications, injections, and improved transplant methods.
This 2017 document explores current and emerging therapeutic strategies for androgenetic alopecia (AGA), a common hair loss condition affecting roughly 50% of the adult population. The authors suggest that topically applied medications or intra-dermal injected or implanted materials are preferable treatment modalities, minimizing side effect risks as compared to systemically applied treatments. They propose that therapeutics which reverse the androgen-driven inhibition of hair follicle signaling pathways, such as prostaglandin analogs and antagonists, platelet-rich plasma (PRP), promotion of skin angiogenesis and perfusion, introduction of progenitor cells for hair regeneration, and more effective ways of transplanting hair, are the likely near future direction of AGA treatment development. The document reviews experimental and early investigational drugs for AGA, characterizes the follicular microinflammation and fibrosis shown in AGA, and identifies the source and functioning of androgens involved in AGA.View this study on tandfonline.com →
New compounds were found to help increase hair growth and decrease hair loss.
Using platelet-rich plasma, which is full of growth factors, can help treat pattern hair loss.
Genes play a significant role in male-pattern baldness, and understanding them could lead to new treatments and insights into related health issues.
Different types of hair loss need specific treatments, and while many classification systems exist, each has its flaws; more research is needed to refine these systems and treatments.
Low-level laser therapy is safe and can increase hair growth for male and female pattern hair loss.
Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.
Blocking JAK-STAT signaling can lead to hair growth.
DNA variants can predict male pattern baldness, with higher risk scores increasing baldness likelihood.
Microneedling can effectively promote new hair growth in men with hair loss who didn't improve with traditional treatments.
Prostaglandin F2α analogs show promise for treating certain types of hair loss but need more research for other skin conditions.
Topical drugs and near-infrared light therapy show potential for treating alopecia.
Platelet-rich plasma, which carries growth factors, could be a promising treatment for non-scarring hair loss, promoting hair growth and density with no major side effects.
Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
PRP injections increase hair density and satisfaction in androgenetic alopecia patients.
DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.
PRP injections may improve hair loss condition, but more research needed.
Finasteride cream helps hair growth with less side effects.
The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.
The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
Effective treatments for male pattern baldness include oral finasteride and topical minoxidil, while topical minoxidil is best for female pattern baldness.
ATE is linked to FAA, and treatment depends on cause; minoxidil helps, finasteride may worsen.
Low-level light therapy may help hair regrowth, but more research is needed.
Low-level laser therapy helps male and female hair loss alone or with other treatments.
Prostaglandin D₂ might be targeted for new male pattern baldness treatments.
Minoxidil with tretinoin boosts hair growth most effectively, followed by minoxidil alone, and then ketoconazole.
Laser device increases hair density, safe for treating hair loss in men and women.
Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.
Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.
Vertex pattern hair loss linked to higher prostate cancer risk.
Hair loss links to higher death risk from diabetes and heart disease; not a direct cause, but a marker for risk factors.
Possible new treatments for common hair loss include drugs, stem cells, and improved transplants.
LCN may improve finasteride delivery for hair loss treatment.
Alopecia patients struggle with emotions and stress, and improving emotional intelligence may help manage hair loss.
Finasteride 5 mg/day effectively treats hair loss in postmenopausal women without hyper-androgenism.
Growth factors and microneedle therapy increase hair density in women with hair loss.
Female pattern hair loss diagnosed by scalp appearance, treated with combined therapies and targeted approaches.
Both genetic and lifestyle factors significantly affect female hair loss.
Melatonin solution helps treat hair loss in men and women.
PRP helps hair growth in common hair loss disorder.
17α-Estradiol solution safely improves hair density and thickness in female pattern hair loss.
Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.
Six new genetic regions linked to early hair loss also connect to Parkinson's disease and prostate cancer, possibly leading to new treatments.
Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.
Latanoprost 0.1% may effectively treat hair loss.
PGD2 stops hair growth and is higher in bald men with AGA.
Platelet-rich plasma with a new carrier significantly increases hair thickness without serious side effects.
Female pattern hair loss can be treated with medications, surgery, and cosmetic products, considering its psychological impact.
A gene called HDAC9 might be a new factor in male-pattern baldness.
Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.
Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.
Male pattern baldness involves hormones and cell signals affecting hair growth.
Transcutol P best increases Finasteride absorption for hair loss treatment.
Hair loss treatments include medications and new methods like low-level light therapy, which may work by boosting cell activity and blood flow.
The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.
A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.
AR gene not major factor in female hair loss; different from male hair loss.
Some treatments work for common baldness, but there's less evidence for other hair loss types, and more research is needed.
Adenosine lotion improves hair growth and thickness in women with hair loss.
Different hair growth problems are caused by genetic issues or changes in hair growth cycles, and new treatments are being developed.
Minoxidil works better for female hair loss than alfatradiol, both safe.
Liposomes improve finasteride delivery for hair loss treatment, making it a promising option for topical use.
Minoxidil and retinol together help hair grow.
Ketoconazole lotion can improve hair regrowth for some people with androgenetic alopecia.
Shorter, thinner hairs indicate AGA, while longer, thicker hairs suggest CTE; counting and measuring shed hairs helps diagnose hair loss type.
Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.
Oral antiandrogens effectively treat female hair loss, with better results in higher hair loss grades.
Hair loss increases with age; alcohol raises risk, more female partners lowers it.
Hair loss needs more research for better treatments.
AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.
Fluridil safely promotes hair growth in men with androgenetic alopecia.
Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.
Ketoconazole shampoo improves hair growth and reduces oil similarly to minoxidil in male pattern hair loss.
RU58841, a nonsteroidal anti-androgen, showed potential as a topical treatment for hair loss, increasing hair density, thickness, and length without systemic side effects in Stumptailed Macaques.
People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
Minoxidil boosts hair growth by activating PGHS-1.
Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.
RU 58841 may treat acne, hair loss, and excessive hair growth.