TLDR Topical drugs and near-infrared light therapy show potential for treating alopecia.
This document from 8 years ago discusses drug discovery efforts for different types of alopecia, including androgenic alopecia, alopecia areata, and chemotherapy-induced alopecia. The article covers the biology of hair follicles, stem cells, and in vitro/in vivo models for drug discovery. The document also discusses investigational drug therapies and non-drug therapies for alopecia, including low-level laser therapy, hair transplantation, and stem cell therapies. The article concludes that topical drug application is the preferred route for treatment and highlights the potential of near-infrared light therapy, specifically low-level laser therapy, as a treatment for all three forms of alopecia.View this study on tandfonline.com →
Dutasteride helps hair growth in those unresponsive to finasteride, but may cause more sexual dysfunction.
New finasteride solution effectively reduces baldness-causing hormone, potentially with fewer side effects.
Laser device increases hair density, safe for treating hair loss in men and women.
Hair follicle culture helps develop new treatments for hair loss.
Female pattern hair loss is common, linked to polycystic ovarian syndrome, and treated with topical Minoxidil.
Minoxidil and finasteride effectively treat hair loss.
The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.
Growth factors and microneedle therapy increase hair density in women with hair loss.
Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.
Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.
Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.
PGD2 stops hair growth and is higher in bald men with AGA.
Platelet-rich plasma with a new carrier significantly increases hair thickness without serious side effects.
Laser treatment increases hair density and thickness safely in women with hair loss.
Flutamide improves female hair loss when other treatments fail, but may cause liver toxicity.
Laser treatment can stimulate hair growth for male pattern hair loss.
Spironolactone helps regrow hair in women with hair loss.
Mice with human gene experienced hair loss when treated with DHT.
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
Hormonal therapies like cyproterone acetate and spironolactone may help some women with hair loss, but finasteride 1mg is not useful, and the effectiveness of other treatments is still unclear.
Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.
Dutasteride successfully treated a woman's hair loss when other treatments failed.
Melatonin helps hair growth in women with hair loss.
Fluridil safely promotes hair growth in men with androgenetic alopecia.
The stump-tailed macaque is a good model for studying human hair loss, but it's expensive and hard to find, while rodent models are promising for understanding hair growth and finding new treatments.
Stump-tailed macaque best for researching hair loss causes and treatments.
RU58841, a nonsteroidal anti-androgen, showed potential as a topical treatment for hair loss, increasing hair density, thickness, and length without systemic side effects in Stumptailed Macaques.
Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.
Using minoxidil and tofacitinib together can effectively treat severe hair loss.
JAK inhibitors help hair regrowth but not fully effective for androgenetic alopecia.
Topical drugs and near-infrared light therapy show potential for treating alopecia.