Immunocytochemical Localization of Androgen Receptors in the Scalp of the Stumptail Macaque Monkey, a Model of Androgenetic Alopecia

    April 1994 in “ Journal of Investigative Dermatology ”
    A. R. Diani, Cynthia G. Mills
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    TLDR Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
    This study used immunocytochemistry to locate androgen receptors (ARs) in the scalp of stumptail macaque monkeys, a model for androgenetic alopecia. The study found that ARs were present in the dermal sheath, outer root sheath, hair epithelium, and dermal papilla of the hair follicle, as well as in sebaceous and sweat glands. The distribution of ARs in the pilosebaceous unit of the stumptail macaque was found to be virtually identical to that in humans, suggesting that androgens regulate similar cellular targets in both species. The study provides additional evidence that scalp hair growth is at least partially mediated by androgens in this primate model.
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