Immunocytochemical Localization of Androgen Receptors in the Scalp of the Stumptail Macaque Monkey, a Model of Androgenetic Alopecia

April 1994 in “ Journal of Investigative Dermatology ”

A. R. Diani, Cynthia G. Mills

androgen receptors ARs androgenetic alopecia dermal sheath outer root sheath hair epithelium dermal papilla hair follicle sebaceous glands sweat glands pilosebaceous unit androgens androgen receptors androgenetic alopecia hair follicle sebaceous glands sweat glands androgens

TLDR Androgen receptors found in monkey scalps, similar to humans, affect hair growth.

This study used immunocytochemistry to locate androgen receptors (ARs) in the scalp of stumptail macaque monkeys, a model for androgenetic alopecia. The study found that ARs were present in the dermal sheath, outer root sheath, hair epithelium, and dermal papilla of the hair follicle, as well as in sebaceous and sweat glands. The distribution of ARs in the pilosebaceous unit of the stumptail macaque was found to be virtually identical to that in humans, suggesting that androgens regulate similar cellular targets in both species. The study provides additional evidence that scalp hair growth is at least partially mediated by androgens in this primate model.

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Research cited in this study

4 / 4 results

Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

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research The Effects of Topical Diazoxide on Hair Follicular Growth and Physiology of the Stumptailed Macaque

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Immunocytochemical Localization of Androgen Receptors in the Scalp of the Stumptail Macaque Monkey, a Model of Androgenetic Alopecia

research Immunocytochemical Localization of Androgen Receptors in the Scalp of the Stumptail Macaque Monkey, a Model of Androgenetic Alopecia

13 citations, April 1994 in “Journal of Investigative Dermatology”

Androgen receptors found in monkey scalps, similar to humans, affect hair growth.

research Hormones and Hair Growth: Variations in Androgen Receptor Content of Dermal Papilla Cells Cultured from Human and Red Deer Hair Follicles

34 citations, July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human hair growth is influenced by androgen hormones, and red deer mane follicles have similar hormone receptors.

Immunocytochemical Localization of Androgen Receptors in the Scalp of the Stumptail Macaque Monkey, a Model of Androgenetic Alopecia

Research cited in this study

research Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

research The Effects of Topical Diazoxide on Hair Follicular Growth and Physiology of the Stumptailed Macaque

research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-Pattern Baldness

research Action of Topical Minoxidil in the Bald Stump-Tailed Macaque

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