TLDR Cuscuta reflexa extracts helped regrow hair in rats with drug-induced hair loss.
The study from 2014 investigated the effects of Cuscuta reflexa extracts on cyclophosphamide (CYP)-induced alopecia in male Swiss albino rats. The rats were divided into four groups, with one group receiving only distilled water, another receiving CYP to induce alopecia, and the remaining two groups receiving CYP plus either petroleum ether extract or ethanolic extract of Cuscuta reflexa at a dose of 250 mg/kg. The study, which involved 24 rats, found that the groups treated with the extracts showed hair regrowth, with the highest hair density and anagen/telogen ratio observed in the group treated with petroleum ether extract, followed by the ethanolic extract group, and the lowest in the CYP-only group. The study concluded that both extracts were effective in promoting hair regrowth and preventing hair loss induced by CYP, potentially by preventing p53 accumulation or downregulation, thus inhibiting apoptosis of hair follicles.
38 citations,
March 2012 in “Zhongxiyi jiehe xuebao” Cuscuta reflexa Roxb. is a parasitic herb with many medicinal benefits.
63 citations,
August 2008 in “Journal of Cosmetic Dermatology” Cuscuta reflexa extract may help treat hair loss caused by hormones.
67 citations,
May 2007 in “Journal of Cosmetic Dermatology” The herbal formulation promoted hair growth faster and more effectively than minoxidil in rats.
12 citations,
January 2004 in “International Journal of aromatherapy/International journal of aromatherapy” Ocimum oil may promote hair growth and reduce hair loss from cyclophosphamide.
153 citations,
January 2001 in “Science” Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” HDAC inhibitors, like Vorinostat and Entinostat, can help regrow hair in alopecia areata.
December 2015 in “Journal of Psoriasis and Psoriatic Arthritis” A patient experienced long-lasting hair loss after using acitretin for psoriasis.
July 2013 in “DeckerMed Medicine” The document's conclusion cannot be provided because the document is not readable or understandable.
Alopecia areata, a type of hair loss, may be passed through T cells and has genetic links, while treatments vary in effectiveness. Male pattern baldness can be treated with finasteride and is influenced by androgens in hair follicles.
