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Research

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research Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

25 citations , January 2024 in “Journal of Lipids”

This review reports that cubosomes, used as drug nanocarriers in topical treatments, offer potential benefits for managing skin and eye diseases by improving bioadhesion, retention, and sustained release compared to conventional formulations, but also face manufacturing and biological challenges for effective clinical outcomes.

Topical Application of Anti-Cancer Drug Bortezomib Stimulates Proliferation of Follicular Cells and Induces Expression of Hair Keratins via GATA-3 Transcription Factor

research 440 Topical application of anti-cancer drug Bortezomib stimulates proliferation of follicular cells and induces expression of hair keratins via GATA-3 transcription factor

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that topical bortezomib increased cell proliferation in hair follicles and sebaceous glands in mice and may activate hair keratin gene expression through GATA-3 transcription factors.

research Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application

16 citations , December 2022 in “Expert Opinion on Drug Delivery”

This study reviewed preclinical and clinical research and found that AFL-assisted topical drug delivery is considered safe and effective, enhancing drug efficacy, reducing treatment time and pain, and improving cosmetic and safety outcomes, but larger clinical trials are needed to confirm these benefits.

research Physical methods for topical skin drug delivery: concepts and applications

22 citations , November 2018 in “Brazilian Journal of Pharmaceutical Sciences”

This review discusses iontophoresis, low-frequency ultrasound, and microneedles for enhancing topical drug delivery in dermatological treatments and reports no clinical results; it emphasizes their mechanisms and potential uses.

research Therapeutic Application of Microsponges-based Drug Delivery Systems

4 citations , January 2022 in “Current pharmaceutical design”

This review discusses the benefits and applications of microsponges delivery systems in drug delivery, particularly for topical treatments, and reports no new clinical findings.

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Community Join

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community Topical application of Apple Skin 15% Procyanidin B2 extract makes hair noticeably thicker

7 upvotes 4 years ago

Hair loss discussion includes homemade 15% Procyanidin B2 apple skin extract as alternative to Minoxidil. User reports thicker hair, but no new growth yet.

community Topical minoxidil brand (and form of application) matters. You can be a hyper-responder to one product and a non-responder to another.

18 upvotes 1 year ago

Different minoxidil formulations affect hair growth and side effects. Higher propylene glycol and pH levels improve effectiveness but can cause scalp irritation.

community Prevention of age-related beard graying in humans by the topical application of Eriodictyon angustifolium extract

5 upvotes 4 years ago

Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.

community Haircafe - TOPICAL minoxidil is an anti aging drug

in Minoxidil 245 upvotes 1 year ago

Topical minoxidil may cause skin aging effects like wrinkles and dark circles, possibly due to its alcohol content, while oral finasteride is reported to make users look younger. Switching to oral minoxidil or using moisturizers might help reduce these skin issues.

community deeper understanding of microneedling

16 upvotes 3 years ago

Microneedling can enhance hair growth by increasing drug absorption and activating stem cells, with different needle depths serving distinct purposes. Users report success with microneedling, often in combination with treatments like minoxidil and finasteride, and emphasize waiting periods for topical application to avoid side effects.

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Learn

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learn Latanoprost

glaucoma medication with hair follicle stimulant effects

learn Vascular Endothelial Growth Factor

learn Thymosin Beta 4

learn Overview

learn sh-Polypeptide-7

learn Verteporfin

Is Verteporfin used as a topical treatment, injection, or oral medication for hair loss? Verteporfin is an intravenous drug approved only for an eye condition; it is not approved for hair loss in any form. In the few published hair reports it was injected into the scalp alongside surgical wounding — unverified case reports of one and two patients, not trial evidence.

learn Valproic acid

How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.

learn Finasteride

Are there really risks with topical finasteride? Reports on topical finasteride describe scalp irritation and dermatitis as the effects specific to it, and blood levels lower than the oral drug; whether systemic side effects are genuinely rarer has not been measured in a trial powered to answer it. Both forms are prescription-only and contraindicated around pregnancy.

learn Spironolactone

How does spironolactone help reduce hair loss when used in topical or oral treatments? Studies report that spironolactone slows androgen-driven follicle miniaturisation by blocking androgen receptors, with most evidence in women and mostly alongside minoxidil; it is a prescription drug and its use for hair loss is off-label.

learn Minoxidil

From hypertension to hair: the unexpected story of minoxidil Minoxidil was developed as an oral blood-pressure drug and approved as Loniten in 1979; unwanted hair growth in patients led to topical Rogaine, approved for men in 1988 and for women in 1991. Trials support topical minoxidil for pattern hair loss, while low-dose oral minoxidil is a prescription drug used off-label and needs medical supervision.

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Clinics

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15
Hair Loss Treatments
Dr Joydeep Roy's Skin Clinic, New S.S.Medicos, (near Cachar high school), Malugram/ Drugs Corner, itkhola near Cachar CollegeSilchar, Assam · IN

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