Laser Microporation Facilitates Topical Drug Delivery: A Comprehensive Review About Preclinical Development and Clinical Application

AFL (Ablative Fractional Laser) was found to be safe and effective in facilitating topical drug delivery, with clinical studies indicating enhanced drug efficacy, shorter treatment times, reduced pain, improved cosmetic outcomes, reduced systemic drug exposure, and improved safety. However, most clinical trials had small sample sizes and were in early phases, suggesting that future studies should involve larger groups for a more comprehensive evaluation of AFL's safety and efficacy. Additionally, the development of smaller and more affordable AFL devices could aid in the broader application of AFL-assisted topical drug delivery.