Enhancement of Drug Permeation Across Skin Through Stratum Corneum Ablation

    January 2024 in “ RSC pharmaceutics ”
    Ahmed Abdoh, David Liu, Yousuf Mohammed
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    TLDR Removing the outer skin layer increases drug absorption and offers non-invasive treatment options, with some methods allowing for quick skin recovery.
    The document reviews methods for enhancing transdermal drug delivery (TDD) by ablating the stratum corneum (SC). It highlights the PassPort™ system's effectiveness in creating micropores for drug delivery, with studies showing increased skin permeability and rapid recovery. Other methods discussed include radiofrequency (RF) microporation, which increased permeability for fluorescein isothiocyanate-dextrans (FITC-dextrans), and RF combined with microneedles (RFMN), which improved hair count and thickness in male pattern hair loss treatment. Ablative fractional lasers (AFLs) and the P.L.E.A.S.E.Ⓡ laser were also mentioned for their ability to create microchannels with minimal skin damage. Suction ablation, while effective, is considered invasive with risks of infection and scarring. AFL-Er:YAG was most effective in treating hypertrophic scars and xanthelasma palpebrarum lesions, while AFL-CO2 was better for acne scars. The document concludes that SC ablation methods significantly enhance drug absorption, offering a non-invasive alternative for various treatments, with technologies like PassPort™, RF microporation, and fractional lasers improving bioavailability and allowing for quick SC recovery. Suction ablation is less favored due to its invasiveness. Understanding the skin permeation characteristics of these devices is crucial for their application in delivering specific medications.
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