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This study highlights the significance of the hf pathway for the skin permeation of ionized and hydrophilic high molecular compounds, and the usefulness of hf-plugging in evaluating their skin permeability.

This source discusses using stratum corneum ablation as a promising method to enhance transdermal drug delivery by temporarily removing the skin's outermost barrier to improve medication absorption.

This study found that hair follicle-plugging reduced skin permeation of certain model drugs, with effects varying based on EtOH pretreatment and the drug being evaluated.

This study found that fractional laser treatment significantly enhances the penetration and targeting of certain permeants, such as imiquimod and FD, to skin follicles, but not hydroquinone.

This study found that nanoparticles did not permeate intact rat skin but could penetrate skin that had been artificially punctured, primarily through grooves or hair follicles.